Prognostic significance of NAP1L1 expression in patients with early lung adenocarcinoma
| العنوان: | Prognostic significance of NAP1L1 expression in patients with early lung adenocarcinoma |
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| المؤلفون: | Satoshi Igawa, Yuichi Sato, Seiichiro Kusuhara, Yoshiki Murakumo, Katsuhiko Naoki, Masaaki Ichinoe, Ryo Nagashio, Yuki Kuchitsu, Yukitoshi Satoh, Makoto Saegusa |
| المصدر: | Biomedical Research. 41:149-159 |
| بيانات النشر: | Biomedical Research Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, Lymphovascular invasion, Adenocarcinoma of Lung, Disease, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Risk Factors, Carcinoma, Non-Small-Cell Lung, Internal medicine, Biomarkers, Tumor, medicine, Humans, Neoplasm Invasiveness, RNA, Small Interfering, Lung cancer, Pathological, Early Detection of Cancer, Aged, Cell Proliferation, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, A549 cell, Nucleosome Assembly Protein 1, Lung, business.industry, General Medicine, Middle Aged, Prognosis, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, A549 Cells, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Adenocarcinoma, Immunohistochemistry, Female, business |
| الوصف: | NAP1L1 is a key regulator of embryonic neurogenesis but its role in lung cancer remains unexplored. In this study, we investigated the relationship between NAP1L1 expression and the clinicopathological parameters and prognosis of non-small cell lung cancer patients. To this end, the expression of NAP1L1 in tumor samples was evaluated by immunohistochemistry. NAP1L1 expression was significantly associated with reduced differentiation (P = 0.00014), higher pathological TNM stages (P < 0.00001), lymph node metastasis (P < 0.00001), intrapulmonary metastasis (P = 0.02955), lymphatic invasion (P = 0.00019), vascular invasion (P = 0.00008) and poorer prognosis (P = 0.0008) of patients with adenocarcinoma. Moreover, multivariate analyses using the Cox-proportional hazards model confirmed that NAP1L1 expression increased the risk of death after adjusting for other clinicopathological factors (HR = 2.46, 95% CI, 1.22-4.96). Furthermore, NAP1L1 expression was identified as an independent poor prognostic factor in patients with resectable stage I lung adenocarcinoma. NAP1L1-siRNA-treated lung adenocarcinoma-derived A549 cells showed significant suppression of proliferation, migration, and invasion abilities. These findings suggest that NAP1L1 may be a novel predictive and prognostic marker in lung adenocarcinoma, particularly in those with stage I of the disease. |
| تدمد: | 1880-313X 0388-6107 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38e9780b4c64e129d1d68871540da13Test https://doi.org/10.2220/biomedres.41.149Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e38e9780b4c64e129d1d68871540da13 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1880313X 03886107 |
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