Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis.

التفاصيل البيبلوغرافية
العنوان:	Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis.
المؤلفون:	Gonzalo, Elena, Toldos, Oscar, Martínez-Vidal, María P, Ordoñez, María C, Santiago, Begoña, Fernández-Nebro, Antonio, Loza, Estíbaliz, García, Isabel, León, Myriam, Pablos, José L, Galindo, María
المساهمون:	Gonzalo, Elena, Santiago, Begoña, Pablos, José L, Galindo, María Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain. Toldos, Oscar Servicio de Anatomía Patológica, Hospital 12 de Octubre, Madrid, Spain. Martínez-Vidal, María P, Galindo, María Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain. Ordoñez, María C, Fernández-Nebro, Antonio Servicio de Reumatología, Hospital Regional Universitario Carlos Haya. Málaga, Spain. Loza, Estíbaliz Unidad de Investigación de la Fundación Española de Reumatología, Sociedad Española de Reumatología, Madrid, Spain. García, Isabel, León, Myriam Servicio de Anatomía Patológica, Hospital Regional Universitario Carlos Haya, Málaga, Spain., This study was supported by Fondo de Investigación Sanitaria (PI06/90374) and RIER (Red de Inflamación y Enfermedades Reumáticas RD08/0075).
بيانات النشر:	BiomedCentral Springer Verlag (Germany)
سنة النشر:	2012
المجموعة:	Sistema Sanitario Público de Andalucía (SSPA): Repositorio
مصطلحات موضوعية:	Activación de Complemento, Inmunohistoquímica, Inflamación, Riñón, Nefritis Lúpica, Macrófagos, Fragmentos de Péptidos, Trombosis, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged, Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Complement Activation, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Complement System Proteins::Complement C4::Complement C4b, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Histological Techniques::Histocytochemistry::Immunohistochemistry, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation, Medical Subject Headings::Anatomy::Urogenital System::Urinary Tract::Kidney, Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Lupus Erythematosus, Systemic::Lupus Nephritis, Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Phagocytes::Macrophages, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged, and Proteins::Peptides::Peptide Fragments, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence, Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Embolism and Thrombosis::Thrombosis, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young Adult
الوصف:	Journal Article; Research Support, Non-U.S. Gov't; ; INTRODUCTION Microthrombosis is often observed in lupus nephritis (LN) lesions, but its clinical significance is unknown. We evaluated the clinicopathologic correlations of renal microthrombosis and inflammatory markers in LN. METHODS Kidney biopsies from 58 patients with systemic lupus erythematosus (SLE) proliferative nephritis were analyzed with immunohistochemistry (IHC) for intravascular platelet aggregates (CD61), macrophagic infiltration (CD68), and activated complement deposition (C4d). Clinical data at the time of kidney biopsy and follow-up were analyzed with regard to pathologic IHC data. RESULTS Microthrombosis was present in 52% of the tissues. It was significantly more prevalent in patients with antiphospholipid antibodies (aPLs) (62% versus 42%). The presence of microthrombosis significantly correlated with higher macrophagic infiltration. Macrophagic infiltration but not microthrombosis was significantly correlated with C4d deposition. Only macrophagic infiltration showed a correlation with SLE and renal activity (proteinuria and active sediment), whereas neither the presence of CD61+ microthrombi nor the extent of C4d deposition correlated with LN severity or outcome. CONCLUSIONS Microthrombosis is associated with higher macrophagic infiltration in LN but does not seem to increase independently the severity of renal damage. Macrophagic infiltration was the best marker of SLE and renal activity in this LN series. ; Yes
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	application/pdf
اللغة:	English
تدمد:	1478-6354 1478-6362
العلاقة:	http://arthritis-research.com/content/14/3/R126Test; Gonzalo E, Toldos O, Martínez-Vidal MP, Ordoñez MC, Santiago B, Fernández-Nebro A, et al. Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis. Arthritis Res. Ther. 2012; 14(3):R126; http://hdl.handle.net/10668/1448Test; PMC3446507
DOI:	10.1186/ar3856
الإتاحة:	https://doi.org/10.1186/ar3856Test http://hdl.handle.net/10668/1448Test
حقوق:	open access
رقم الانضمام:	edsbas.17D3248
قاعدة البيانات:	BASE

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الوصف
تدمد:	14786354 14786362
DOI:	10.1186/ar3856