التفاصيل البيبلوغرافية
| العنوان: |
Measurement of the efficacy of 2% lipid in reversing bupivacaine- induced asystole in isolated rat hearts |
| المؤلفون: |
Chen, Hongfei, Xia, Yun, Zhu, Binbin, Hu, Xiawei, Xu, Shihao, Chen, Limei, Papadimos, Thomas J, Wang, Wantie, Wang, Quanguang, Xu, Xuzhong |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2014 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Anaesthetics local-bupivacaine, Complications-cardiac arrest, Lipid emulsion |
| الوصف: |
Background The reversal efficacy of 2% lipid emulsion in cardiac asystole induced by different concentrations of bupivacaine is poorly defined and needs to be determined. Methods Forty-two male Sprague–Dawley rats were randomly divided into seven groups: B40, B60, B80, B100, B120, B140 and B160, n = 6. The Langendorff isolated heart perfusion model was used, which consisted of a balanced perfusion with Krebs-Henseleit solution for 25 minutes and a continuous infusion of 100 μmol/L bupivacaine until asystole had been induced for 3 minutes. The hearts in the seven groups were perfused with Krebs-Henseleit solution containing a 2% lipid emulsion, and 40, 60, 80, 100, 120, 140 or 160 μmol/L bupivacaine, respectively. Cardiac recovery was defined as a spontaneous and regular rhythm with a rate-pressure product > 10% of the baseline value for more than 1 minute. Our primary outcome was the rate-pressure product 25 minutes after cardiac recovery. Other cardiac function parameters were also recorded. Results All groups demonstrated cardiac recovery. During the recovery phase, heart rate, rate-pressure product, the maximum left ventricular pressure rise and decline in heart rate in the B120-B160 groups was significantly lower than those in the B40-B80 groups ( P < 0.05). The concentration of bupivacaine and the reversal effects of a 2% lipid emulsion showed a typical transoid S-shaped curve, R 2 = 0.9983, IC 50 value was 102.5 μmol/L (95% CI: 92.44 - 113.6). Conclusions There is a concentration-response relationship between the concentrations of bupivacaine and the reversal effects of 2% lipid emulsion. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://www.biomedcentral.com/1471-2253/14/60Test |
| الإتاحة: |
http://www.biomedcentral.com/1471-2253/14/60Test |
| حقوق: |
Copyright 2014 Chen et al.; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.F23C5A96 |
| قاعدة البيانات: |
BASE |
