التفاصيل البيبلوغرافية
| العنوان: |
Helicobacter pylori infection might be responsible for the interconnection between type 1 diabetes and autoimmune thyroiditis |
| المؤلفون: |
El-Eshmawy, Mervat M, El-Hawary, Amany K, Abdel Gawad, Soma S, El-Baiomy, Azza A |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2011 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Helicobacter pylori, type1 diabetes mellitus, autoimmune thyroiditis |
| الوصف: |
Background Higher serological prevalence rates of helicobacter pylori (H. pylori) infection have been reported in patients with type 1 diabetes (T1DM) and autoimmune thyroiditis (AT). Patients with T1DM are at increased risk for developing other autoimmune diseases, most commonly AT. It is unknown whether H. pylori infection could explain the high prevalence of thyroid autoantibodies and AT in T1DM. The aim of the current study was to evaluate anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) autoantibodies in correlation with anti-H. pylori IgG and IgA in young patients with T1DM. Methods Anti-H. Pylori IgG, IgA, anti-TPO and anti-Tg antibodies titers were measured in 162 euthyroid patients with T1DM and 80 healthy controls matched for age, sex and socioeconomic status. Results Seroprevalence of H. pylori was significantly higher in patients with T1DM than in healthy controls; 79% vs. 51.2%, p < 0.001. Anti H. pylori IgG was positive in 61.1% of patients with T1DM and 30% of controls, p < 0.001, anti H. pylori IgA was positive in 74% of patients with T1DM and 32.5% of controls, p < 0.001. Thyroid autoimmunity was also significantly higher in patients with T1DM than in controls; 56.7% vs. 6.2%, p < 0.001. Anti-TPO was positive in 25.3% of patients with T1DM and 3.7% of controls, p < 0.001, anti-Tg was positive in 47.5% of patients with T1DM and 6.2% of controls, p < 0.001. With simple and multiple regression analysis anti-H. pylori IgG and IgA titers were positively and significantly correlated with Anti-TPO and anti-Tg titers in patients with T1DM. Conclusion our results support the idea of a connection between H. pylori infection and the occurrence of anti-TPO, anti-Tg autoantibodies and AT in young patients with T1DM. So, H. pylori infection could be considered as an environmental trigger for development of AT in T1DM. Young patients with T1DM should be screened for H. pylori infection. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.dmsjournal.com/content/3/1/28Test |
| الإتاحة: |
http://www.dmsjournal.com/content/3/1/28Test |
| حقوق: |
Copyright 2011 El-Eshmawy et al; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.46F69D24 |
| قاعدة البيانات: |
BASE |
