التفاصيل البيبلوغرافية
| العنوان: |
Strength Training for Arthritis Trial (START): design and rationale |
| المؤلفون: |
Messier, Stephen P, Mihalko, Shannon L, Beavers, Daniel P, Nicklas, Barbara J, DeVita, Paul, Carr, J, Hunter, David J, Williamson, Jeff D, Bennell, Kim L, Guermazi, Ali, Lyles, Mary, Loeser, Richard F |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2013 |
| المجموعة: |
BioMed Central |
| الوصف: |
Background Muscle loss and fat gain contribute to the disability, pain, and morbidity associated with knee osteoarthritis (OA), and thigh muscle weakness is an independent and modifiable risk factor for it. However, while all published treatment guidelines recommend muscle strengthening exercise to combat loss of muscle mass and strength in knee OA patients, previous strength training studies either used intensities or loads below recommended levels for healthy adults or were generally short , lasting only 6 to 24 weeks. The efficacy of high-intensity strength training in improving OA symptoms, slowing progression, and affecting the underlying mechanisms has not been examined due to the unsubstantiated belief that it might exacerbate symptoms. We hypothesize that in addition to short-term clinical benefits, combining greater duration with high-intensity strength training will alter thigh composition sufficiently to attain long-term reductions in knee-joint forces, lower pain levels, decrease inflammatory cytokines, and slow OA progression. Methods/Design This is an assessor-blind, randomized controlled trial. The study population consists of 372 older (age ≥ 55 yrs) ambulatory, community-dwelling persons with: (1) mild-to-moderate medial tibiofemoral OA (Kellgren-Lawrence (KL) = 2 or 3); (2) knee neutral or varus aligned knee ( -2° valgus ≤ angle ≤ 10° varus); (3) 20 kg . m -2 ≥ BMI ≤ 45 kg . m -2 ; and (3) no participation in a formal strength-training program for more than 30 minutes per week within the past 6 months. Participants are randomized to one of 3 groups: high-intensity strength training (75-90% 1Repetition Maximum (1RM)); low-intensity strength training (30-40%1RM); or healthy living education. The primary clinical aim is to compare the interventions’ effects on knee pain, and the primary mechanistic aim is to compare their effects on knee-joint compressive forces during walking, a mechanism that affects the OA disease pathway. Secondary aims will compare the interventions’ effects on ... |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.biomedcentral.com/1471-2474/14/208Test |
| الإتاحة: |
http://www.biomedcentral.com/1471-2474/14/208Test |
| حقوق: |
Copyright 2013 Messier et al.; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.CDBAA43C |
| قاعدة البيانات: |
BASE |
