دورية أكاديمية
Predicting the occurrence of embolic events: An analysis of 1456 episodes of infective endocarditis from the Italian Study on Endocarditis (SEI)
| العنوان: | Predicting the occurrence of embolic events: An analysis of 1456 episodes of infective endocarditis from the Italian Study on Endocarditis (SEI) |
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| المؤلفون: | Rizzi M., Ravasio V., Carobbio A., Mattucci I., Crapis M., Stellini R., Pasticci M. B., Chinello P., Falcone M., Grossi P., Barbaro F., Pan A., Viale P., Durante-Mangoni E., Alberto Biglino, Maria Teresa Brusa, Paolo Crivelli, Roberta Moglia, Sebastiano Leone, Veronica Ravasio, Marco Rizzi, Fredy Suter, Pierluigi Viale, Peter Mian, Greta Spoladore, Francesco Castelli, Silvia Magri, Roberto Stellini, Domenico Di Caprio, Evelyn Van Hauwermeiren, Angelo Pan, Fabio Zacchi, Nicoletta Barzaghi, Marco Libanore, Mario Pantaleoni, Valerio Del Bono, Claudio Viscoli, Gianni Gattuso, Alfredo Scalzini, Maria Riccarda Villa, Mariano Bernardo, Roberta Casillo, Susanna Cuccurullo, Giovanni Dialetto, Emanuele Durante-Mangoni, Irene Mattucci, Enrico Ragone, Marie-Françoise Tripodi, Riccardo Utili, Francesco Barbaro, Elke Erne, Lorenzo Minoli, Elena Maria Seminari, Laura Martinelli, Carlo Pallotto, Maria Bruna Pasticci, Benedetta Canovari, Laura Stoppini, Pierangelo Chinello, Marco Falcone, Nicola Petrosillo, Mario Venditti, Palma Delle Foglie, Mario Giobbia, Walter Inoiosa, Giorgio Scotton, Alberto Vaglia, Matteo Bassetti, Massimo Crapis, Sergio Venturini, Daniela Dalla Gasperina, Paolo Grossi, Alessandro Tebini, Ercole Concia, Paola Del Bravo, Andrea Tedesco, Roberto Nicolin, Giampietro Pellizzer |
| المساهمون: | M., Rizzi, V., Ravasio, A., Carobbio, I., Mattucci, M., Crapi, R., Stellini, M. B., Pasticci, P., Chinello, M., Falcone, P., Grossi, F., Barbaro, A., Pan, P., Viale, E., Durante-Mangoni, Biglino, Alberto, Teresa Brusa, Maria, Crivelli, Paolo, Moglia, Roberta, Leone, Sebastiano, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Viale, Pierluigi, Mian, Peter, Spoladore, Greta, Castelli, Francesco, Magri, Silvia, Stellini, Roberto, Di Caprio, Domenico, Van Hauwermeiren, Evelyn, Pan, Angelo, Zacchi, Fabio, Barzaghi, Nicoletta, Libanore, Marco, Pantaleoni, Mario, Del Bono, Valerio, Viscoli, Claudio, Gattuso, Gianni, Scalzini, Alfredo, Riccarda Villa, Maria, Bernardo, Mariano, Casillo, Roberta, Cuccurullo, Susanna, Dialetto, Giovanni, Durante-Mangoni, Emanuele, Mattucci, Irene, Ragone, Enrico, Tripodi, Marie-Françoise, Utili, Riccardo, Barbaro, Francesco, Erne, Elke, Minoli, Lorenzo, Maria Seminari, Elena, Martinelli, Laura, Pallotto, Carlo, Bruna Pasticci, Maria, Canovari, Benedetta, Stoppini, Laura, Chinello, Pierangelo, Falcone, Marco, Petrosillo, Nicola, Venditti, Mario, Delle Foglie, Palma, Giobbia, Mario, Inoiosa, Walter, Scotton, Giorgio, Vaglia, Alberto, Bassetti, Matteo, Crapis, Massimo, Venturini, Sergio, Dalla Gasperina, Daniela, Grossi, Paolo, Tebini, Alessandro, Concia, Ercole, Del Bravo, Paola, Tedesco, Andrea, Nicolin, Roberto, Pellizzer, Giampietro |
| بيانات النشر: | BioMed Central Ltd. CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| سنة النشر: | 2014 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | Embolism, Infective endocarditi, Risk score, Stroke, Adult, Aged, Endocarditis, Bacterial, Female, Human, Italy, Male, Middle Aged, Retrospective Studie, Risk Factor |
| الوصف: | Background: Embolic events are a major cause of morbidity and mortality in patients with infective endocarditis. We analyzed the database of the prospective cohort study SEI in order to identify factors associated with the occurrence of embolic events and to develop a scoring system for the assessment of the risk of embolism.Methods: We retrospectively analyzed 1456 episodes of infective endocarditis from the multicenter study SEI. Predictors of embolism were identified. Risk factors identified at multivariate analysis as predictive of embolism in left-sided endocarditis, were used for the development of a risk score: 1 point was assigned to each risk factor (total risk score range: minimum 0 points; maximum 2 points). Three categories were defined by the score: low (0 points), intermediate (1 point), or high risk (2 points); the probability of embolic events per risk category was calculated for each day on treatment (day 0 through day 30).Results: There were 499 episodes of infective endocarditis (34%) that were complicated by ≥ 1 embolic event. Most embolic events occurred early in the clinical course (first week of therapy: 15.5 episodes per 1000 patient days; second week: 3.7 episodes per 1000 patient days). In the total cohort, the factors associated with the occurrence of embolism at multivariate analysis were prosthetic valve localization (odds ratio, 1.84), right-sided endocarditis (odds ratio, 3.93), Staphylococcus aureus etiology (odds ratio, 2.23) and vegetation size ≥ 13 mm (odds ratio, 1.86). In left-sided endocarditis, Staphylococcus aureus etiology (odds ratio, 2.1) and vegetation size ≥ 13 mm (odds ratio, 2.1) were independently associated with embolic events; the 30-day cumulative incidence of embolism varied with risk score category (low risk, 12%; intermediate risk, 25%; high risk, 38%; p < 0.001).Conclusions: Staphylococcus aureus etiology and vegetation size are associated with an increased risk of embolism. In left-sided endocarditis, a simple scoring system, which combines etiology and ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/24779617; info:eu-repo/semantics/altIdentifier/wos/WOS:000336070300001; volume:14; firstpage:230; lastpage:230; numberofpages:1; journal:BMC INFECTIOUS DISEASES; https://hdl.handle.net/11567/999087Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84900436055 |
| DOI: | 10.1186/1471-2334-14-230 |
| الإتاحة: | https://doi.org/10.1186/1471-2334-14-230Test https://hdl.handle.net/11567/999087Test |
| رقم الانضمام: | edsbas.7951103D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/1471-2334-14-230 |
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