التفاصيل البيبلوغرافية
| العنوان: |
Clinical aspects of a nationwide epidemic of severe haemolytic uremic syndrome (HUS) in children |
| المؤلفون: |
Krogvold, Lars, Henrichsen, Thore, Bjerre, Anna, Brackman, Damien, Dollner, Henrik, Gudmundsdottir, Helga, Syversen, Gaute, Næss, Pål, Bangstad, Hans |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2011 |
| المجموعة: |
BioMed Central |
| الوصف: |
Background Report a nationwide epidemic of Shiga toxin-producing E. coli (STEC) O103:H25 causing hemolytic uremic syndrome (D+HUS) in children. Methods Description of clinical presentation, complications and outcome in a nationwide outbreak. Results Ten children (median age 4.3 years) developed HUS during the outbreak. One of these was presumed to be a part of the outbreak without microbiological proof. Eight of the patients were oligoanuric and in need of dialysis. Median need for dialysis was 15 days; one girl did not regain renal function and received a kidney transplant. Four patients had seizures and/or reduced consciousness. Cerebral oedema and herniation caused the death of a 4-year-old boy. Two patients developed necrosis of colon with perforation and one of them developed non-autoimmune diabetes. Conclusion This outbreak of STEC was characterized by a high incidence of HUS among the infected children, and many developed severe renal disease and extrarenal complications. A likely explanation is that the O103:H25 ( eae and stx 2 -positive) strain was highly pathogen, and we suggest that this serotype should be looked for in patients with HUS caused by STEC, especially in severe forms or outbreaks. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://www.sjtrem.com/content/19/1/44Test |
| الإتاحة: |
http://www.sjtrem.com/content/19/1/44Test |
| حقوق: |
Copyright 2011 Krogvold et al; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.7B11CB53 |
| قاعدة البيانات: |
BASE |
