التفاصيل البيبلوغرافية
| العنوان: |
p21-activated kinase signaling in breast cancer |
| المؤلفون: |
Gururaj, Anupama E, Rayala, Suresh K, Kumar, Rakesh |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2004 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
breast cancer, hormone independence, mouse model, p21-activated kinase, Rho GTPase |
| الوصف: |
The p21-activated kinases signal through a number of cellular pathways fundamental to growth, differentiation and apoptosis. A wealth of information has accumulated at an impressive pace in the recent past, both with regard to previously identified targets for p21-activated kinases that regulate the actin cytoskeleton and cellular stress pathways and with regard to newly identified targets and their role in cancer. Emerging data also provide new clues towards a previously unappreciated link between these various cellular processes. The present review attempts to provide a quick tutorial to the reader about the evolving significance of p21-activated kinases and small GTPases in breast cancer, using information from mouse models, tissue culture studies, and human materials. |
| نوع الوثيقة: |
review |
| اللغة: |
English |
| العلاقة: |
http://breast-cancer-research.com/content/7/1/5Test |
| الإتاحة: |
http://breast-cancer-research.com/content/7/1/5Test |
| حقوق: |
Copyright 2004 BioMed Central Ltd |
| رقم الانضمام: |
edsbas.11738E41 |
| قاعدة البيانات: |
BASE |
