Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease: protocol of the BEAT-IT study
| العنوان: | Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease: protocol of the BEAT-IT study |
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| المؤلفون: | Frank Jan de Jong, Lilian J H M Vroegindeweij, Jan J M Driesen, Anke A. Dijkstra, Rik Ossenkoppele, Marc A. Koopmanschap, Janne M. Papma, Jeannette A Goudzwaard, Francesco Mattace Raso, Sytse U Zuidema, Willem S. Eikelboom, Rozemarijn L van Bruchem, Philip Scheltens, Tom den Heijer, Susanne E. Hoogers, Elsbeth C Thomeer, Esther van den Berg, Yolande A.L. Pijnenburg, Michiel Coesmans, Ellen H. Singleton, John C. van Swieten |
| المساهمون: | Life Course Epidemiology (LCE), Neurology, Pathology, Divisions, Amsterdam Neuroscience - Neurodegeneration, Psychiatry, Internal Medicine, Health Technology Assessment (HTA) |
| المصدر: | Alzheimer's Research & Therapy Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019) Eikelboom, W S, Singleton, E, van den Berg, E, Coesmans, M, Mattace Raso, F, van Bruchem, R L, Goudzwaard, J A, de Jong, F J, Koopmanschap, M, den Heijer, T, Driesen, J J M, Vroegindeweij, L J H M, Thomeer, E C, Hoogers, S E, Dijkstra, A A, Zuidema, S U, Pijnenburg, Y A L, Scheltens, P, van Swieten, J C, Ossenkoppele, R & Papma, J M 2019, ' Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease: Protocol of the BEAT-IT study ', Alzheimer's Research and Therapy, vol. 11, no. 1, 48 . https://doi.org/10.1186/s13195-019-0503-2Test Alzheimers research & therapy, 11(1):48. BioMed Central Ltd. Alzheimer's Research and Therapy, 11(1):48. BioMed Central Alzheimers Research & Therapy, 11:48. BioMed Central Ltd. |
| بيانات النشر: | BioMed Central Ltd., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Quality of life, medicine.medical_specialty, Cognitive Neuroscience, Cost-Benefit Analysis, Psychological intervention, Disease, Behavioral Symptoms, Neuropsychological Tests, Psychological Distress, lcsh:RC346-429, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Outcome Assessment, Health Care, medicine, Dementia, Humans, Cognitive Dysfunction, Intensive care medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:Neurology. Diseases of the nervous system, Geriatrics, Psychiatric Status Rating Scales, Behavior, business.industry, Research, Memory clinic, Caregiver burden, medicine.disease, Neuropsychiatry, 030104 developmental biology, Neurology, Caregivers, Research Design, Neurology (clinical), business, Alzheimer’s disease, Prospective studies, 030217 neurology & neurosurgery, Geriatric psychiatry, Follow-Up Studies |
| الوصف: | BACKGROUND: Neuropsychiatric symptoms (NPS) are very common in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia and are associated with various disadvantageous clinical outcomes including a negative impact on quality of life, caregiver burden, and accelerated disease progression. Despite growing evidence of the efficacy of (non)pharmacological interventions to reduce these symptoms, NPS remain underrecognized and undertreated in memory clinics. The BEhavioural symptoms in Alzheimer's disease Towards early Identification and Treatment (BEAT-IT) study is developed to (1) investigate the neurobiological etiology of NPS in AD and (2) study the effectiveness of the Describe, Investigate, Create, Evaluate (DICE) approach to structure and standardize the current care of NPS in AD. By means of the DICE method, we aim to improve the quality of life of AD patients with NPS and their caregivers who visit the memory clinic. This paper describes the protocol for the intervention study that incorporates the latter aim.METHODS: We aim to enroll a total of 150 community-dwelling patients with MCI or AD and their caregivers in two waves. First, we will recruit a control group who will receive care as usual. Next, the second wave of participants will undergo the DICE method. This approach consists of the following steps: (1) describe the context in which NPS occur, (2) investigate the possible causes, (3) create and implement a treatment plan, and (4) evaluate whether these interventions are effective. Primary outcomes are the quality of life of patients and their caregivers. Secondary outcomes include NPS change, caregiver burden, caregivers' confidence managing NPS, psychotropic medication use, the experiences of patients and caregivers who underwent the DICE method, and the cost-effectiveness of the intervention.CONCLUSIONS: This paper describes the protocol of an intervention study that is part of the BEAT-IT study and aims to improve current recognition and treatment of NPS in AD by structuring and standardizing the detection and treatment of NPS in AD using the DICE approach.TRIAL REGISTRATION: The trial was registered on the Netherlands Trial Registry ( NTR7459 ); registered 6 September 2018. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1758-9193 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f7b971c2129e4897bd8ae5a1003c15Test https://pure.eur.nl/en/publications/d7185f33-0a38-4c58-b012-dc380aaa282cTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....73f7b971c2129e4897bd8ae5a1003c15 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17589193 |
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