دورية أكاديمية
Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network
| العنوان: | Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network |
|---|---|
| المؤلفون: | Karch, CM, Hernandez, D, Wang, J-C, Marsh, J, Hewitt, AW, Hsu, S, Norton, J, Levitch, D, Donahue, T, Sigurdson, W, Ghetti, B, Farlow, M, Chhatwal, J, Berman, S, Cruchaga, C, Morris, JC, Bateman, RJ, Pebay, A, Goate, AM |
| بيانات النشر: | BioMed Central Ltd. |
| سنة النشر: | 2018 |
| المجموعة: | University of Tasmania: UTas ePrints |
| مصطلحات موضوعية: | amyloid precursor protein, Dominantly Inherited Alzheimer Network, fibroblasts, induced pluripotent stem cells, presenilin 1, presenilin 2 |
| الوصف: | Background: Mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) cause autosomal dominant forms of Alzheimer disease (ADAD). More than 280 pathogenic mutations have been reported in APP, PSEN1, and PSEN2. However, understanding of the basic biological mechanisms that drive the disease are limited. The Dominantly Inherited Alzheimer Network (DIAN) is an international observational study of APP, PSEN1, and PSEN2 mutation carriers with the goal of determining the sequence of changes in presymptomatic mutation carriers who are destined to develop Alzheimer disease.Results: We generated a library of 98 dermal fibroblast lines from 42 ADAD families enrolled in DIAN. We have reprogrammed a subset of the DIAN fibroblast lines into patient-specific induced pluripotent stem cell (iPSC) lines. These cells were thoroughly characterized for pluripotency markers.Conclusions: This library represents a comprehensive resource that can be used for disease modeling and the development of novel therapeutics. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://eprints.utas.edu.au/27849/1/127798%20Journal%20Article.pdfTest; Karch, CM, Hernandez, D, Wang, J-C, Marsh, J, Hewitt, AW orcid:0000-0002-5123-5999 , Hsu, S, Norton, J, Levitch, D, Donahue, T, Sigurdson, W, Ghetti, B, Farlow, M, Chhatwal, J, Berman, S, Cruchaga, C, Morris, JC, Bateman, RJ, Pebay, A and Goate, AM 2018 , 'Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network' , Alzheimer's Research and Therapy, vol. 10, no. 1 , pp. 1-11 , doi: https://doi.org/10.1186/s13195-018-0400-0Test . |
| الإتاحة: | https://doi.org/10.1186/s13195-018-0400-0Test https://eprints.utas.edu.au/27849Test/ https://eprints.utas.edu.au/27849/1/127798%20Journal%20Article.pdfTest |
| رقم الانضمام: | edsbas.ACCCE763 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |