التفاصيل البيبلوغرافية
| العنوان: |
Epidemiological changes in meningococcal meningitis in Niger from 2008 to 2011 and the impact of vaccination |
| المؤلفون: |
Collard, Jean-Marc, Issaka, Bassira, Zaneidou, Maman, Hugonnet, Stéphane, Nicolas, Pierre, Taha, Muhamed-Kheir, Greenwood, Brian, Jusot, Jean-François |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2013 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Neisseria meningitidis serogroup A and W, Meningitis, Niger, Vaccination, MenAfriVac®, Sequence-type lineage evolution, Immunization |
| الوصف: |
Background The epidemiology of bacterial meningitis in the African ‘meningitis belt’ changes periodically. In order to design an effective vaccination strategy, we have examined the epidemiological and microbiological patterns of bacterial meningitis, and especially that of meningococcal meningitis, in Niger during the period 2008–2011. During this period a mass vaccination campaign with the newly developed meningococcal A conjugate vaccine (MenAfriVac®) was undertaken. Method Cerebrospinal fluid samples were collected from health facilities throughout Niger and analysed by culture, seroagglutination and/or speciation polymerase chain reaction, followed by genogrouping PCR for Neisseria meningitidis infections. A sample of strains were analysed by multi-locus sequence typing. Results N. meningitidis serogroup A cases were prevalent in 2008 and 2009 [98.6% and 97.5% of all N. meningitidis cases respectively]. The prevalence of serogroup A declined in 2010 [26.4%], with the emergence of serogroup W Sequence Type (ST) 11 [72.2% of cases], and the serogroup A meningococcus finally disappeared in 2011. The geographical distribution of cases N. meningitidis serogroups A and W within Niger is described. Conclusion The substantial decline of serogroup A cases that has been observed from 2010 onwards in Niger seems to be due to several factors including a major polysaccharide A/C vaccination campaign in 2009, the introduction of MenAfriVac® in 10 districts at risk in December 2010, the natural dynamics of meningococcal infection and the persistence of serogroup A sequence-type 7 for about 10 years. The emergence of serogroup W strains suggests that there may be a need for serogroup W containing vaccines in Niger in the coming years. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://www.biomedcentral.com/1471-2334/13/576Test |
| الإتاحة: |
http://www.biomedcentral.com/1471-2334/13/576Test |
| حقوق: |
Copyright 2013 Collard et al.; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.6D1C9F1C |
| قاعدة البيانات: |
BASE |
