Alcohol consumption and microvascular dysfunction
| العنوان: | Alcohol consumption and microvascular dysfunction |
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| المؤلفون: | van der Heide, Frank C. T., Eussen, Simone J. P. M., Houben, Alfons J. H. M., Henry, Ronald M. A., Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Koster, Annemarie, Jansen, Jacobus F. A., Backes, Walter H., Beulens, Joline W. J., Stehouwer, Coen D. A. |
| المساهمون: | RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Interne Geneeskunde, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), RS: CAPHRI School for Public Health and Primary Care, Oogheelkunde, MUMC+: MA UECM Onderzoekers (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: MHeNs - R3 - Neuroscience, MUMC+: University Eye Center Maastricht (3), RS: NUTRIM - R3 - Respiratory & Age-related Health, Sociale Geneeskunde, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Beeldvorming, MUMC+: DA BV Research (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: DA BV Klinisch Fysicus (9), MUMC+: MA Interne Geneeskunde (3), Epidemiology and Data Science, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, APH - Health Behaviors & Chronic Diseases |
| المصدر: | Cardiovascular Diabetology, 22(1):67. BioMed Central Ltd Cardiovascular Diabetology, 22(1):67. BioMed Central van der Heide, F C T, Eussen, S J P M, Houben, A J H M, Henry, R M A, Kroon, A A, van der Kallen, C J H, Dagnelie, P C, van Dongen, M C J M, Berendschot, T T J M, Schouten, J S A G, Webers, C A B, van Greevenbroek, M M J, Wesselius, A, Schalkwijk, C G, Koster, A, Jansen, J F A, Backes, W H, Beulens, J W J & Stehouwer, C D A 2023, ' Alcohol consumption and microvascular dysfunction : a J-shaped association: The Maastricht Study ', Cardiovascular Diabetology, vol. 22, no. 1, 67 . https://doi.org/10.1186/s12933-023-01783-xTest |
| بيانات النشر: | BioMed Central Ltd, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, Cerebral small vessel disease, Wine, Spirits, Cardiovascular risk factor, Heat-induced skin hyperemia, Alcohol Drinking/adverse effects, Microvasculature, Diabetes Mellitus, Humans, Albuminuria, Retinal microvascular diameters, Plasma biomarkers, Cardiovascular Diseases/diagnosis, Flicker light-induced increase in retinal microvascular diameter, Ethanol, Smoking, Beer, Type 2 diabetes, Middle Aged, Endothelial cell dysfunction, Cross-Sectional Studies, Glucose, Diabetes Mellitus, Type 2, Dyslipidemia, Microvascular dysfunction, Hypertension, History of cardiovascular disease, Female, Cardiology and Cardiovascular Medicine, Alcohol, Type 2 |
| الوصف: | Background Microvascular dysfunction (MVD) is an important contributor to major clinical disease such as stroke, dementia, depression, retinopathy, and chronic kidney disease. Alcohol consumption may be a determinant of MVD. Objective Main objectives were (1) to study whether alcohol consumption was associated with MVD as assessed in the brain, retina, skin, kidney and in the blood; and (2) to investigate whether associations differed by history of cardiovascular disease or sex. Design We used cross-sectional data from The Maastricht Study (N = 3,120 participants, 50.9% men, mean age 60 years, and 27.5% with type 2 diabetes [the latter oversampled by design]). We used regression analyses to study the association between total alcohol (per unit and in the categories, i.e. none, light, moderate, high) and MVD, where all measures of MVD were combined into a total MVD composite score (expressed in SD). We adjusted all associations for potential confounders; and tested for interaction by sex, and history of cardiovascular disease. Additionally we tested for interaction with glucose metabolism status. Results The association between total alcohol consumption and MVD was non-linear, i.e. J-shaped. Moderate versus light total alcohol consumption was significantly associated with less MVD, after full adjustment (beta [95% confidence interval], -0.10 [-0.19; -0.01]). The shape of the curve differed with sex (Pinteraction = 0.03), history of cardiovascular disease (Pinteraction interaction = 0.02). Conclusions The present cross-sectional, population-based study found evidence that alcohol consumption may have an effect on MVD. Hence, although increasing alcohol consumption cannot be recommended as a policy, this study suggests that prevention of MVD may be possible through dietary interventions. |
| اللغة: | English |
| تدمد: | 1475-2840 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e6617993bb23d24a2955f6bbc25775Test https://cris.maastrichtuniversity.nl/en/publications/db66e383-9a37-43a5-83f8-38687a211728Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....61e6617993bb23d24a2955f6bbc25775 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752840 |
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