دورية أكاديمية
Patient selection for CAR T or BiTE therapy in multiple myeloma: Which treatment for each patient?
| العنوان: | Patient selection for CAR T or BiTE therapy in multiple myeloma: Which treatment for each patient? |
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| المؤلفون: | Kegyes, David, Constantinescu, Catalin, Vrancken, Louise, Rasche, Leo, Grégoire, Céline, Tigu, Bogdan, Gulei, Diana, Dima, Delia, Tanase, Alina, Einsele, Hermann, Ciurea, Stefan, Tomuleasa, Ciprian, Caers, Jo |
| المصدر: | Journal of Hematology and Oncology, 15 (1), 78 (2022-06-07) |
| بيانات النشر: | BioMed Central Ltd, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adoptive cell therapy, BAT, BiTE, Bispecific T cell engager, Bispecific antibody, Bispecific antibody armed T cell, CAR T, Chimeric antigen receptor, Immunotherapy, Multiple myeloma, Stem cell transplantation, Receptors, Chimeric Antigen, Humans, Immunotherapy, Adoptive, Patient Selection, Multiple Myeloma/drug therapy, Receptors, Chimeric Antigen/therapeutic use, Molecular Biology, Hematology, Oncology, Cancer Research, Human health sciences, Immunology & infectious disease, Laboratory medicine & medical technology, Sciences de la santé humaine, Hématologie, Immunologie & maladie infectieuse, Médecine de laboratoire & technologie médicale |
| الوصف: | Multiple myeloma (MM) is a plasma cell malignancy that affects an increasing number of patients worldwide. Despite all the efforts to understand its pathogenesis and develop new treatment modalities, MM remains an incurable disease. Novel immunotherapies, such as CAR T cell therapy (CAR) and bispecific T cell engagers (BiTE), are intensively targeting different surface antigens, such as BMCA, SLAMF7 (CS1), GPRC5D, FCRH5 or CD38. However, stem cell transplantation is still indispensable in transplant-eligible patients. Studies suggest that the early use of immunotherapy may improve outcomes significantly. In this review, we summarize the currently available clinical literature on CAR and BiTE in MM. Furthermore, we will compare these two T cell-based immunotherapies and discuss potential therapeutic approaches to promote development of new clinical trials, using T cell-based immunotherapies, even as bridging therapies to a transplant. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article peer reviewed |
| اللغة: | English |
| العلاقة: | https://link.springer.com/content/pdf/10.1186/s13045-022-01296-2.pdfTest; urn:issn:1756-8722 |
| DOI: | 10.1186/s13045-022-01296-2 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/294232Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.294232 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1186/s13045-022-01296-2 |
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