Serum human epididymis protein 4 level as a predictor of clinical worsening in idiopathic pulmonary arterial hypertension: a pilot study
| العنوان: | Serum human epididymis protein 4 level as a predictor of clinical worsening in idiopathic pulmonary arterial hypertension: a pilot study |
|---|---|
| المؤلفون: | Chang-Ming Xiong, Yi Tang, Yinkun Yan, Lu Yan, Xin-Hai Ni, Qin Luo, Qi Jin, Xue Yu, Qing Zhao, Zhiwei Huang, Zhihong Liu, Zhihui Zhao, Wenlin Xie |
| المصدر: | BMC Cardiovascular Disorders BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-6 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Pilot Projects, 030204 cardiovascular system & hematology, Gastroenterology, Severity of Illness Index, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Human epididymis protein 4, WAP Four-Disulfide Core Domain Protein 2, Predictive Value of Tests, Internal medicine, medicine, Humans, Familial Primary Pulmonary Hypertension, Survival rate, Idiopathic pulmonary arterial hypertension, 030304 developmental biology, Angiology, 0303 health sciences, Proportional hazards model, business.industry, Hazard ratio, Area under the curve, Cardiac function, Cardiac surgery, Up-Regulation, lcsh:RC666-701, Case-Control Studies, Disease Progression, Biomarker (medicine), Female, Cardiology and Cardiovascular Medicine, business, Biomarkers, Blood sampling, Research Article, Predictor, Clinical worsening |
| الوصف: | BackgroundHuman epididymis protein 4 (HE4) was proved to be a novel biomarker for left heart failure. The purpose of this exploratory study was to evaluate the role of HE4 in patients with idiopathic pulmonary arterial hypertension (IPAH) who usually have concurrent right heart failure.Methods55 patients with newly diagnosed IPAH were continuously enrolled and serum HE4 levels were assessed at baseline. All patients were followed up from the date of blood sampling, and a composite endpoint of clinical worsening was detailedly recorded.ResultsSerum levels of HE4 were significantly higher in IPAH patients than healthy controls (6.9 ± 2.2 vs 4.4 ± 0.9 ng/ml,p r = 0.331,p r = 0.30,p 6.5 ng/ml discriminated clinical worsening with a sensitivity of 92.31% and a specificity of 59.52% (area under the curve [AUC] = 0.81). Multivariate Cox regression analysis demonstrated that HE4 (χ2: 5.10; hazard ratio [HR] = 1.26; 95% confidence interval: 1.03 to 1.55,p 2: 4.19; HR = 1.14; 95% confidence interval: 1.00–1.29,p 6.5 ng/ml had a worse 2-year survival rate than those with HE4 ≤ 6.5 ng/ml (58.9% vs 96.2%,p ConclusionsSerum levels of HE4 were elevated in IPAH patients and correlated with disease severity. HE4 was an independent predictor of clinical worsening in IPAH patients. |
| اللغة: | English |
| تدمد: | 1471-2261 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9beae45f16ce1906c63fff6b04c6c163Test http://europepmc.org/articles/PMC7160929Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9beae45f16ce1906c63fff6b04c6c163 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712261 |
|---|