التفاصيل البيبلوغرافية
| العنوان: |
The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells. |
| المؤلفون: |
Li, Jiangping1 (AUTHOR) lijiangping@wchscu.cn, Xiao, Zhiwen2 (AUTHOR), Wang, Donghui3 (AUTHOR), Jia, Lei4 (AUTHOR), Nie, Shihong5 (AUTHOR), Zeng, Xingda6 (AUTHOR), Hu, Wei7 (AUTHOR) |
| المصدر: |
Molecular Cancer. 8/30/2023, Vol. 22 Issue 1, p1-56. 56p. |
| مصطلحات موضوعية: |
*CLINICAL medicine, *MEDICAL screening, *IMMUNE checkpoint proteins, *CANCER vaccines, *OVERALL survival |
| مستخلص: |
Recent advances in neoantigen research have accelerated the development of tumor immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody-based therapies, particularly for solid tumors. With the development of next-generation sequencing and bioinformatics technology, the rapid identification and prediction of tumor-specific antigens (TSAs) has become possible. Compared with tumor-associated antigens (TAAs), highly immunogenic TSAs provide new targets for personalized tumor immunotherapy and can be used as prospective indicators for predicting tumor patient survival, prognosis, and immune checkpoint blockade response. Here, the identification and characterization of neoantigens and the clinical application of neoantigen-based TCR-T immunotherapy strategies are summarized, and the current status, inherent challenges, and clinical translational potential of these strategies are discussed. Key points: 1) Established the computational process and platform of neoantigen prediction, and comprehensive prediction and screening of tumor specific neoantigens. 2) Rapid identification of neoantigen-specific TCRs for personalized engineered TCR-T cell therapy. 3) Classification and characteristics of tumor specific neoantigen-based therapy, and combined antitumor strategies. 4) The current status, inherent challenges, and clinical translational potential of TCR-T therapy. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder