التفاصيل البيبلوغرافية
| العنوان: |
Pseudotumor cerebri presenting with visual failure in promyelocytic leukemia: a case report. |
| المؤلفون: |
Rasul, Fahid T.1 (AUTHOR) fahidrasul@doctors.org.uk, Toma, Ahmed K.1 (AUTHOR), Khan, Akbar A.1 (AUTHOR), Plant, Gordon T.1 (AUTHOR), Watkins, Laurence D.1 (AUTHOR) |
| المصدر: |
Journal of Medical Case Reports. 2012, Vol. 6 Issue 1, p408-411. 4p. 2 Diagrams. |
| مستخلص: |
Unlabelled: Introduction: Pseudotumor cerebri secondary to all-trans retinoic acid in acute promyelocytic leukemia is a reported but rare complication of the therapy. Most cases improve following the discontinuation of all-trans retinoic acid. There is no published literature on how to manage such patients if severe symptoms of increased intracranial pressure continue after discontinuation of the drug.Case Presentation: We report the case of a 16-year-old Afro-Caribbean woman with aggressive secondary pseudotumor cerebri who presented to our facility with visual failure that persisted despite discontinuation of all-trans retinoic acid. A lumbar drain was inserted for 11 days resulting in symptomatic relief of headaches and objective improvement of visual failure. Pressure settings were titrated regularly to ensure optimal symptomatic relief.Conclusions: The use of a lumbar drain for continuous drainage of cerebrospinal fluid in patients with all-trans retinoic acid-induced pseudotumor cerebri resistant to all-trans retinoic acid discontinuation is a feasible management option. This method can be used when other less invasive measures have failed to improve signs and symptoms. Permanent drainage of cerebrospinal fluid with a shunt may also provide a long-term viable management strategy but the use of a lumbar drain may be preferable if the cause of pseudotumor cerebri is known to be self-limiting. [ABSTRACT FROM AUTHOR] |
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