Metabolic syndrome severity is significantly associated with future coronary heart disease in Type 2 diabetes
| العنوان: | Metabolic syndrome severity is significantly associated with future coronary heart disease in Type 2 diabetes |
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| المؤلفون: | Stephanie L. Filipp, Mark D. DeBoer, Yi Guo, Matthew J. Gurka |
| المصدر: | Cardiovascular Diabetology Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-9 (2018) |
| بيانات النشر: | BioMed Central, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Risk, Blood Glucose, Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Blood Pressure, Coronary Disease, Type 2 diabetes, 030204 cardiovascular system & hematology, Risk Assessment, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, Internal medicine, medicine, Humans, Angiology, Original Investigation, Glycated Hemoglobin, Metabolic Syndrome, business.industry, Hazard ratio, Diabetes, Middle Aged, medicine.disease, Cardiovascular disease, Prognosis, Lipids, Coronary heart disease, Confidence interval, United States, 3. Good health, Atherosclerosis Risk in Communities, Diabetes Mellitus, Type 2, lcsh:RC666-701, Disease Progression, Female, Metabolic syndrome, Waist Circumference, Cardiology and Cardiovascular Medicine, business, Biomarkers |
| الوصف: | Background The severity of the metabolic syndrome (MetS) is significantly associated with future coronary heart disease (CHD) among individuals without baseline Type 2 diabetes. However, the validity of assessing MetS severity among individuals with diabetes is unknown. Objective To assess for differences in MetS severity by timing of Type 2 diabetes diagnosis and to assess for associations between MetS severity and future CHD among individuals with diabetes. Methods We analyzed data from participants of the Atherosclerosis Risk in Communities study, including 1419 with- and 7241 without diabetes, followed during 4 visits and adjudicated CHD diagnoses over a 20-year period. We used Cox-regression techniques to assess hazard ratios (HR) of CHD based on a sex- and race/ethnicity-specific MetS-severity Z-score (standard MetS score) and a similar MetS-severity score formulated without incorporating glucose as a component of MetS (no-glucose MetS score). Results For both the standard- and no-glucose MetS-severity scores, scores were highest in the baseline-diabetes group, lowest in the never-diabetes group and intermediate in the incident-diabetes groups. Among participants with diabetes, increasing MetS-severity score at baseline was associated with incident CHD, using both the standard MetS score (HR 1.29, 95% confidence interval [CI] 1.21, 1.39) and the no-glucose score (HR 1.42, CI 1.24, 1.62) (both p |
| اللغة: | English |
| تدمد: | 1475-2840 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de553721f9b6f177b92d6ac0914b633Test http://europepmc.org/articles/PMC5775549Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2de553721f9b6f177b92d6ac0914b633 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752840 |
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