التفاصيل البيبلوغرافية
| العنوان: |
Modification of additive effect between vitamins and ETS on childhood asthma risk according to GSTP1 polymorphism: a cross -sectional study. |
| المؤلفون: |
So-Yeon Lee, Bong-Seong Kim, Sung-Ok Kwon, Se-Young Oh, Hye Lim Shin, Young-Ho Jung, Eun Lee, Song-I Yang, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, Ji-Won Kwon, Hae-Ran Lee, Soo-Jong Hong, Lee, So-Yeon, Kim, Bong-Seong, Kwon, Sung-Ok, Oh, Se-Young, Shin, Hye Lim, Jung, Young-Ho |
| المصدر: |
BMC Pulmonary Medicine; 10/22/2015, Vol. 15, p1-9, 9p, 4 Charts, 2 Graphs |
| مصطلحات موضوعية: |
ASTHMA, DIET, DISEASE susceptibility, GENETIC polymorphisms, PASSIVE smoking, QUESTIONNAIRES, TRANSFERASES, VITAMIN A, VITAMIN C, VITAMIN E, VITAMINS, PHENOTYPES, CROSS-sectional method, BETA carotene, ODDS ratio |
| مستخلص: |
Background: Asthma is characterized by airway inflammation, and bronchial airways are particularly susceptible to oxidant-induced tissue damage.Objective: To investigate the effect of dietary antioxidant intake and environmental tobacco smoke (ETS) on the risk of childhood asthma according to genotypes susceptible to airway diseases.Methods: This cross-sectional study included 1124 elementary school children aged 7-12 years old. Asthma symptoms and smoking history were measured using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Intake of vitamin A (including retinol and β-carotene), C, and E was measured by a semi-quantitative food frequency questionnaire (FFQ). GSTP1 polymorphisms were genotyped from peripheral blood samples.Results: ETS was significantly associated with presence of asthma symptoms (adjusted odds ratio [aOR], 2.48; 95 % confidence interval [CI], 1.29-4.76) and diagnosis (aOR, 1.91; 95 % CI, 1.19-3.06). Dietary antioxidant intake was not associated with asthma symptoms, although ETS plus low vitamin A intake showed a significant positive association with asthma diagnosis (aOR, 2.23; 95 % CI, 1.10-4.54). Children with AA at nucleotide 1695 in GSTP1 who had been exposed to ETS and a low vitamin A intake have an increased risk of asthma diagnosis (aOR, 4.44; 95 % CI,1.58-12.52) compared with children who had not been exposed to the two risk factors. However, ETS exposure and low vitamin A intake did not significantly increase odds of asthma diagnosis in children with AG or GG genotypes.Conclusion: Low vitamin A intake and ETS exposure may increase oxidative stress and thereby risk for childhood asthma. These relationships may be modified by gene susceptibility alleles of GSTP1. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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