Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer
| العنوان: | Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer |
|---|---|
| المؤلفون: | Sibi Raj, Kavindra Kumar Kesari, Arun Kumar, Brijesh Rathi, Ashok Sharma, Piyush Kumar Gupta, Saurabh Kumar Jha, Niraj Kumar Jha, Petr Slama, Shubhadeep Roychoudhury, Dhruv Kumar |
| المساهمون: | Amity University, Department of Applied Physics, Mahavir Cancer Institute & Research Center, University of Delhi, All India Institute of Medical Sciences, Sharda University, Mendel University in Brno, Assam University, Aalto-yliopisto, Aalto University |
| المصدر: | Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022) Molecular Cancer |
| بيانات النشر: | BioMed Central, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Monoclonal antibody, Cancer Research, EGFR, Review, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Tumor Microenvironment, Animals, Humans, RC254-282, Hepatocyte growth factor, Immunity, Disease Management, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Head and neck squamous cell carcinoma, Proto-Oncogene Proteins c-met, stomatognathic diseases, Treatment Outcome, Oncology, Drug Resistance, Neoplasm, Head and Neck Neoplasms, Molecular Medicine, Disease Susceptibility, C-MET, Energy Metabolism, Chemoresistance, Signal Transduction |
| الوصف: | Funding Information: DK: Department of Science and Technology- Science and Engineering Research Board (DST-SERB) funded research grant (ECR/2016/001489), Govt. of India. Funding Information: Authors acknowledge Department of Science and Technology-Science and Engineering Research Board (DST- SERB), Government of India for partial financial support. Publisher Copyright: © 2022, The Author(s). Head and neck cancer is the sixth most common cancer across the globe. This is generally associated with tobacco and alcohol consumption. Cancer in the pharynx majorly arises through human papillomavirus (HPV) infection, thus classifying head and neck squamous cell carcinoma (HNSCC) into HPV-positive and HPV-negative HNSCCs. Aberrant, mesenchymal-epithelial transition factor (c-MET) signal transduction favors HNSCC progression by stimulating proliferation, motility, invasiveness, morphogenesis, and angiogenesis. c-MET upregulation can be found in the majority of head and neck squamous cell carcinomas. c-MET pathway acts on several downstream effectors including phospholipase C gamma (PLCγ), cellular Src kinase (c-Src), phosphotidylinsitol-3-OH kinase (PI3K), alpha serine/threonine-protein kinase (Akt), mitogen-activated protein kinase (MAPK), and wingless-related integration site (Wnt) pathways. c-MET also establishes a crosstalk pathway with epidermal growth factor receptor (EGFR) and contributes towards chemoresistance in HNSCC. In recent years, the signaling communications of c-MET/HGF in metabolic dysregulation, tumor-microenvironment and immune modulation in HNSCC have emerged. Several clinical trials have been established against c-MET/ hepatocyte growth factor (HGF) signaling network to bring up targeted and effective therapeutic strategies against HNSCC. In this review, we discuss the molecular mechanism(s) and current understanding of c-MET/HGF signaling and its effect on HNSCC. Graphical abstract: [Figure not available: see fulltext.] |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67fe13808265fa056ea58fbd5b5350fTest https://aaltodoc.aalto.fi/handle/123456789/112961Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a67fe13808265fa056ea58fbd5b5350f |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |