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COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study

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العنوان: COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study
المؤلفون: Jurado, Aurora, Martín, María C, Abad-Molina, Cristina, Orduña, Antonio, Martínez, Alba, Ocaña, Esther, Yarce, Oscar, Navas, Ana M, Trujillo, Antonio, Fernández, Luis, Vergara, Esther, Rodríguez, Beatriz, Quirant, Bibiana, Martínez-Cáceres, Eva, Hernández, Manuel, Perurena-Prieto, Janire, Gil, Juana, Cantenys, Sergi, González-Martínez, Gema, Martínez-Saavedra, María T, Rojo, Ricardo, Marco, Francisco M, Mora, Sergio, Ontañón, Jesús, López-Hoyos, Marcos, Ocejo-Vinyals, Gonzalo, Melero, Josefa, Aguilar, Marta, Almeida, Delia, Medina, Silvia, Vegas, María C, Jiménez, Yesenia, Prada, Álvaro, Monzón, David, Boix, Francisco, Cunill, Vanesa, Molina, Juan
المساهمون: Jurado A, Yarce,O, Navas,AM, Trujillo,A, Molina,J Department of Immunology and Allergology, Hospital Universitario Reina Sofía-Instituto de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. Martín,MC Centro de Hemoterapia y Hemodonación de Castilla y León, Paseo de Filipinos s/n, 47007, Valladolid, Spain. Abad-Molina,C, Orduña,A Department of Microbiology and Immunology, Hospital Clínico Universitario, Valladolid, Spain. Martínez,A, Ocaña,E Laboratory Unit. Complejo Hospitalario, Jaén, Spain. Fernández,L, Vergara,E Laboratoy of Immunology and Genetics. Hospital San Pedro de Alcántara, Cáceres, Spain. Rodríguez,B Laboratory Unit. Hospital Juan Ramón Jiménez, Huelva, Spain. Quirant,B, Martínez-Cáceres,E Department of Immunology, Hospital Germans Trias i Pujols, Barcelona, Spain. Hernández,M, Perurena-Prieto,J Department of Immunology, Hospital Universitario Vall d’Hebron, Barcelona, Spain. Gil,J, Cantenys,S Department of Immunology, Hospital General Universitario e Instituto de Investigación Sanitaria “Gregorio Marañón”, Madrid, Spain. González-Martínez,G, Martínez-Saavedra,MT Unit of Immunology, Hospital Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain. Rojo,R Department of Immunology, Complejo Hospitalario, La Coruña, Spain. Marco,FM, Mora,S Laboratory Unit. Hospital General, Alicante, Spain. Ontañón,J Laboratory Unit. Hospital General Universitario, Albacete, Spain. López-Hoyos,M, Ocejo-Vinyals,G Department of Immunology, Hospital Universitario Marqués de Valdecilla, Santander, Spain. Melero,J, Aguilar,M Department of Immunology, Hospital Infanta Cristina, Badajoz, Spain. Almeida,D, Medina,S Laboratory Unit. Complejo Hospitalario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain. Vegas,MC, Jiménez,Y Department of Immunology, Fundación Jiménez Díaz, Madrid, Spain. Prada,A, Monzón,D Department of Immunology, Hospital de Donostia, San Sebastián, Spain. Boix,F Department of Immunology, Hospital Clínico Universitario, Salamanca, Spain. Cunill,V Department of Immunology, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
بيانات النشر: BioMed Central
سنة النشر: 2020
المجموعة: Sistema Sanitario Público de Andalucía (SSPA): Repositorio
مصطلحات موضوعية: Severe acute respiratory syndrome coronavirus 2, COVID-19, Immunosenescence, Immunity, Renin-angiotensin system, ACE2, Interleukin-6, C-reactive protein, Lymphocytes, Spain, Betacoronavirus, Inmunosenescencia, Inmunidad, Sistema renina-angiotensina, Interleucina-6, Proteína C-Reactiva, Linfocitos, Angiotensin converting enzyme 2, Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity, Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Renin-Angiotensin System, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-6, and Proteins::Proteins::Blood Proteins::Immunoproteins::C-Reactive Protein, Medical Subject Headings::Anatomy::Hemic and Immune Systems::Blood::Blood Cells::Leukocytes, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections, Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Comorbidity
الوصف: Background: The SARS-CoV-2 infection has widely spread to become the greatest public health challenge to date, the COVID-19 pandemic. Different fatality rates among countries are probably due to non-standardized records being carried out by local health authorities. The Spanish case-fatality rate is 11.22%, far higher than those reported in Asia or by other European countries. A multicentre retrospective study of demographic, clinical, laboratory and immunological features of 584 Spanish COVID-19 hospitalized patients and their outcomes was performed. The use of renin-angiotensin system blockers was also analysed as a risk factor. Results: In this study, 27.4% of cases presented a mild course, 42.1% a moderate one and for 30.5% of cases, the course was severe. Ages ranged from 18 to 98 (average 63). Almost 60 % (59.8%) of patients were male. Interleukin 6 was higher as severity increased. On the other hand, CD8 lymphocyte count was significantly lower as severity grew and subpopulations CD4, CD8, CD19, and NK showed concordant lowering trends. Severity-related natural killer percent descents were evidenced just within aged cases. A significant severity-related decrease of CD4 lymphocytes was found in males. The use of angiotensin-converting enzyme inhibitors was associated with a better prognosis. The angiotensin II receptor blocker use was associated with a more severe course. Conclusions: Age and age-related comorbidities, such as dyslipidaemia, hypertension or diabetes, determined more frequent severe forms of the disease in this study than in previous literature cohorts. Our cases are older than those so far reported and the clinical course of the disease is found to be impaired by age. Immunosenescence might be therefore a suitable explanation for the hampering of immune system effectors. The adaptive immunity would become exhausted and a strong but ineffective and almost deleterious innate response would account for COVID-19 severity. Angiotensin-converting enzyme inhibitors used by hypertensive patients ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 1742-4933
العلاقة: https://immunityageing.biomedcentral.com/articles/10.1186/s12979-020-00194-wTest; Jurado A, Martín MC, Abad-Molina C, Orduña A, Martínez A, Ocaña E, et al. COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study. Immun Ageing. 2020 Aug 14;17:22.; http://hdl.handle.net/10668/3280Test; PMC7426672
DOI: 10.1186/s12979-020-00194-w
الإتاحة: https://doi.org/10.1186/s12979-020-00194-wTest
http://hdl.handle.net/10668/3280Test
حقوق: open access
رقم الانضمام: edsbas.D97414F
قاعدة البيانات: BASE
الوصف
تدمد:17424933
DOI:10.1186/s12979-020-00194-w