المؤلفون: Elshami, Mohamedraed, Sawafta, Nawras, Mansour, Ahmad, Alser, Mohammed, Al-Slaibi, Ibrahim, Abukmail, Hanan, Shurrab, Hanan, Qassem, Shahd, Usrof, Faten Darwish, Alruzayqat, Malik, Aqel, Wafa, Nairoukh, Roba, Kittaneh, Rahaf, Habes, Yousef Mahmoud Nimer, Ghanim, Obaida, Aabed, Wesam Almajd, Omar, Ola, Daraghma, Motaz, Aljbour, Jumana, Elian, Razan E. M.

المصدر: BMC Cancer; 2/7/2024, Vol. 24 Issue 1, p1-13, 13p

مصطلحات موضوعية: HEMOPTYSIS, LUNG cancer, RESOURCE-limited settings, CONVENIENCE sampling (Statistics), HEALTH facilities

مصطلحات جغرافية: PALESTINE

مستخلص: Background: Lung cancer (LC) has poor survival outcomes mainly due to diagnosis at late stages. This study explored the anticipated time to seek medical advice for possible LC symptoms and barriers to early presentation in Palestine. Methods: This cross-sectional study recruited adult participants from hospitals, primary healthcare centers, and public spaces of 11 governorates using convenience sampling. A modified, translated-into-Arabic version of the validated LC awareness measure was used to assess LC symptom awareness, the time needed to seek medical advice and barriers to early presentation. Results: A total of 4762 participants were included. The proportion that would immediately seek medical advice for possible LC symptoms varied according to the symptoms' nature. For respiratory symptoms, this ranged from 15.0% for 'painful cough' to 37.0% for 'coughing up blood'. For non-respiratory symptoms, this ranged from '4.2% for 'unexplained loss of appetite' to 13.8% for 'changes in the shape of fingers or nails'. Participants with good LC symptom awareness were more likely to seek medical advice within a week of recognizing most LC symptoms. About 13.0% would delay their visit to see a doctor after recognizing an LC symptom. The most reported barriers were emotional with 'disliking the visit to healthcare facilities' (59.8%) as the leading barrier. Conclusion: LC respiratory symptoms were more likely to prompt early seeking of medical advice. Good LC symptom awareness was associated with a higher likelihood of help-seeking within a week. Educational interventions are needed to promote LC awareness and address the perceived barriers to early presentation in low-resource settings, such as Palestine. [ABSTRACT FROM AUTHOR]

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المؤلفون: Ziółkowski, Piotr, Woźniak, Marta, Mansour, Ahmad, An, Yu, Weber, Georg F.

المصدر: Breast Cancer Research; 9/29/2022, Vol. 24 Issue 1, p1-10, 10p

مصطلحات موضوعية: PROTEINS, PAPILLOMA, MONOCLONAL antibodies, PROGNOSIS, RESEARCH funding, BREAST tumors

مستخلص: Background: Papillomas of the breast pose challenges for treatment decisions as their risk for transformation to breast cancer is low but not negligible. To spare low-risk patients the burden of substantial treatment side effects, prognostic indicators are needed for cancerous progression. The secreted metastasis mediator Osteopontin (OPN) is a marker for breast cancer aggressiveness, and its variants are prognosticators for transformation in diverse premalignant breast lesions. Here, we test whether the presence of OPN-c or OPN-exon-4 in papillomatous lesions may reflect progression risk.Methods: By immunohistochemistry, we analyze OPN-c and OPN-exon-4 in papillomas from 114 women as well as correlations between staining and progression. In departure from prior spliced OPN biomarker publications, we utilize novel monoclonal antibodies.Results: Fewer than 5% of OPN-c pathology score 0-1 (intensity) versus almost 18% of score 2-3 experienced cancer in follow-up. Nine of 12 women, who progressed, had pathology scores of 2-3 for OPN-c intensity at the time of initial diagnosis, and none had a score of 0. When developing a combined risk score from intensity plus percent positivity for OPN-c, the progression risk for patients with low score was 3.2%, for intermediate score was 5.7%, and for high score was 18.8%. Papillomas in patients, who were later diagnosed with cancer in the contralateral breast, displayed stronger staining positivity than non-progressors.Conclusion: OPN splice variant immunohistochemistry on biopsies of breast papillomas will allow counseling of the patients on their risk to develop breast cancer at a later time. [ABSTRACT FROM AUTHOR]

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المؤلفون: Casella, Antonio M. B., Mansour, Ahmad M., EC, Souza, do Prado, Rodrigo B., Meirelles, Rodrigo, Wong, Keye, Yassine, Salma, Monteiro, Mário Luiz R.

المصدر: International Journal of Retina & Vitreous; 9/24/2022, Vol. 8 Issue 1, p1-11, 11p

مصطلحات موضوعية: GIANT cell arteritis, RETINAL artery occlusion, FLUORESCENCE angiography, RETINAL artery, OPTICAL coherence tomography, TEMPORAL arteries

مستخلص: Purpose: To describe chorioretinal signs in a case series of Giant Cell Arteritis (GCA). Methods: This is a multicenter retrospective observational case series with GCA that presented with a headache and an abrupt, unilateral loss in vision. Workup included temporal artery biopsies, intravenous fluorescein angiography, optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), blood levels of erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Results: There are a total of 8 GCA instances presented. Average age was 74.5. (Range 68–83 years). The patients reported that one eye's visual loss had suddenly started, along with a fresh headache and other systemic symptoms. Eight patients exhibited choroidal ischemia, five paracentral acute middle maculopathy (PAMM) lesions, five cotton wool spots, four anterior ischemic optic neuropathy, and one central retinal arterial occlusion at the time of presentation. The average ESR at presentation was 68 mm/hr (range 4–110), and 4/6 individuals had a significant increase. The mean CRP level was 6.2 mg/dL (range 2.0–15.4), and the level was always over the normal range. All patients' temporal artery biopsies were positive. Conclusion: Alongside PAMM lesions, cotton wool spots, anterior ischemic optic neuropathy, and central retinal artery occlusion, choroidal ischemia is a key angiographic indicator in the diagnosis of GCA. It may be crucial to recognize these typical ischemic chorioretinal signs while diagnosing GCA. [ABSTRACT FROM AUTHOR]

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المؤلفون: Elshami, Mohamedraed, Abukmail, Hanan, Aqel, Wafa, Alser, Mohammed, Al-Slaibi, Ibrahim, Shurrab, Hanan, Qassem, Shahd, Usrof, Faten Darwish, Alruzayqat, Malik, Nairoukh, Roba, Mansour, Ahmad, Kittaneh, Rahaf, Sawafta, Nawras, Habes, Yousef M. N., Ghanim, Obaida, Aabed, Wesam Almajd, Omar, Ola, Daraghmeh, Motaz, Aljbour, Jomana, Elian, Razan

المصدر: BMC Pulmonary Medicine; 4/8/2022, Vol. 22 Issue 1, p1-14, 14p

مصطلحات موضوعية: LUNG cancer, CONVENIENCE sampling (Statistics), AWARENESS, CROSS-sectional method, SHOULDER pain, COUGH

مصطلحات جغرافية: GAZA Strip, WEST Bank, JERUSALEM

مستخلص: Background: The majority of lung cancer (LC) cases are diagnosed at an advanced stage. Poor awareness of LC symptoms is a contributor to late diagnosis. This study aimed to assess the awareness of LC symptoms among Palestinians, and to examine the factors associated with displaying good awareness.Methods: Participants were recruited from hospitals, primary healthcare centers and public spaces using convenience sampling. A translated-into-Arabic version of the validated LC awareness measure was used to assess recognition of 14 LC symptoms. One point was given for each recognized symptom. The total score was calculated and categorized based on the number of symptoms recognized: poor (0-4), fair (5-9), and good (10-14). Multivariable logistic regression was used to examine the association between participant characteristics and having good awareness. The multivariable analysis adjusted for age-group, gender, education, monthly income, occupation, residence, marital status, any chronic disease, knowing someone with cancer, smoking history, and site of data collection.Results: Of 5174 potential participants approached, 4817 completed the questionnaire (response rate = 93.1%) and 4762 were included in the final analysis. Of these, 2742 (56.9%) were from the West Bank and Jerusalem (WBJ) and 2020 (43.1%) were from the Gaza Strip. Participants from the WBJ were older, had higher monthly income but lower education, and suffered from more chronic diseases. The most recognized respiratory LC symptom was 'worsening in an existing cough'(n = 3884, 81.6%) while the least recognized was 'a cough that does not go away for two or three weeks'(n = 2951, 62.0%). The most recognized non-respiratory LC symptom was 'persistent tiredness or lack of energy'(n = 3205, 67.3%) while the least recognized was 'persistent shoulder pain'(n = 1170, 24.6%). A total of 2466 participants (51.8%) displayed good awareness of LC symptoms. Participants from both the Gaza Strip and the WBJ had similar likelihoods to have good awareness levels. Factors associated with a higher likelihood to display good awareness included female gender, having post-secondary education, being employed, knowing someone with cancer, and visiting hospitals and primary healthcare centers.Conclusion: About half of the study participants displayed a good level of awareness of LC symptoms. Further improvement in public awareness of LC symptoms by educational interventions might reduce LC mortality by promoting early diagnosis. [ABSTRACT FROM AUTHOR]

: Copyright of BMC Pulmonary Medicine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Eisenberger, Tobias, Slim, Rima, Bolz, Hanno Jörn, Mansour, Ahmad, Nauck, Markus, Nürnberg, Gudrun, Nürnberg, Peter, Decker, Christian, Dafinger, Claudia, Ebermann, Inga, Bergmann, Carsten

المصدر: Orphanet journal of rare diseases 7, 59 (2012). doi:10.1186/1750-1172-7-59

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:22938382; info:eu-repo/semantics/altIdentifier/wos/WOS:000312256400001; info:eu-repo/semantics/altIdentifier/issn/1750-1172; https://publications.rwth-aachen.de/record/211053Test; https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-073803%22Test

الإتاحة: https://doi.org/10.1186/1750-1172-7-59Test
https://doi.org/10.18154/RWTH-CONV-073803Test
https://publications.rwth-aachen.de/record/211053Test
https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-073803%22Test

المؤلفون: Sweileh, Waleed M., Moh'd Mansour, Ahmad

المصدر: Global Health Research & Policy; 8/3/2020, Vol. 5 Issue 1, p1-11, 11p

المؤلفون: Mansour, Ahmad M., Ashraf, Mohammed, El Jawhari, Khalil M., Farah, Michel, Souka, Ahmed, Sarvaiya, Chintan, Singh, Sumit Randhir, Banker, Alay, Chhablani, Jay

المصدر: International Journal of Retina & Vitreous; 1/14/2020, Vol. 6 Issue 1, p1-4, 4p

مستخلص: Background: To evaluate the safety and efficacy of intravitreal ziv-aflibercept (IVZ) in the management of vitreous hemorrhage (VH) in eyes with previously lasered proliferative diabetic retinopathy (PDR). Methods: In a prospective multicenter study, previously lasered eyes who had dense VH from PDR underwent intravitreal injection of ziv-aflibercept (IVZ) (1.25 mg aflibercept). Demographic characteristics of the patients, baseline and final logMar visual acuity, number of injections, VH clearance time, and need for vitrectomy were recorded. Results: Twenty-seven eyes of 21 patients were included in the study. Mean age of study patients was 61.3 ± 14.1 years with mean duration of diabetes mellitus of 22.6 ± 7.8 years. Mean logMAR BCVA at baseline was 1.41 ± 1.26 (Snellen equivalent 20/514) and at the last visit 0.55 ± 0.61 (Snellen equivalent 20/70) with a mean gain of 0.86 EDTRS line (paired student t test = 5.1; p ≤ 0.001). Mean number of IVZ 2.4 ± 1.6 (range 1–6). The mean follow-up time was 11.7 ± 11.1 months (range 1–34). Mean time for visual recovery and/or VH clearance was 5.7 ± 3.3 weeks. Eyes, which required multiple injections, the interval period between injections for recurrent VH was 6.4 ± 5.2 months. No subject required vitrectomy. No ocular or systemic adverse effects were noted. Conclusions: IVZ injections had good short-term safety and efficacy for the therapy of new or recurrent VH in previously lasered eyes with PDR reducing somewhat the need for vitrectomy. Trial registration: NCT02486484 [ABSTRACT FROM AUTHOR]

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المؤلفون: Mansour, Ahmad M¹ (AUTHOR), Yunis, Muhammad H (AUTHOR), Medawar, Walid A (AUTHOR)

المصدر: Journal of Medical Case Reports. 2011, Vol. 5 Issue 1, p1-4. 4p.

مصطلحات موضوعية: *CATARACT surgery, *MEDICAL radiography, *BLOOD circulation disorders, *BODY fluid disorders, *VISION disorders

مستخلص: Introduction: High-resolution ocular coherence computed tomography enables unprecedented visualization of the retinal microarchitecture. To the best of our knowledge, this is the first report of high-resolution ocular coherence tomography findings in the healed form of photic post-cataract retinopathy.Case Presentation: A 76-year-old Caucasian man complained of paracentral scotoma, persisting for six weeks after cataract surgery.Conclusion: Ocular coherence tomography demonstrated a localized juxta-foveal area of retinal atrophy involving the photoreceptor layer, and the retinal pigment epithelium layer. [ABSTRACT FROM AUTHOR]