التفاصيل البيبلوغرافية
| العنوان: |
A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination. |
| المؤلفون: |
Singer, Josef, Testori, Christoph, Schellongowski, Peter, Handisurya, Ammon, Müller, Catharina, Reitter, Eva-Maria, Graninger, Wolfgang, Knöbl, Paul, Staudinger, Thomas, Winkler, Stefan, Thalhammer, Florian |
| المصدر: |
BMC Infectious Diseases; 6/22/2017, Vol. 17, p1-5, 5p, 1 Chart |
| مصطلحات موضوعية: |
STREPTOCOCCUS pneumoniae, AUTOIMMUNE lymphoproliferative syndrome, SPLENECTOMY, DISEASE susceptibility, PNEUMONIA vaccines, STREPTOCOCCAL disease prevention, PNEUMOCOCCAL vaccines, SEPTIC shock, STREPTOCOCCAL diseases, STREPTOCOCCUS, VACCINES, TREATMENT effectiveness, SEROTYPES, IMMUNOCOMPROMISED patients, DISEASE complications, PHARMACODYNAMICS |
| مستخلص: |
Background and Case Presentation: We report a case of septic shock syndrome caused by Streptococcus pneumoniae in a patient who had undergone splenectomy due to an autoimmune lymphoproliferative syndrome (ALPS), which is characterized as a dysfunction of immunoregulation. Although the patient was vaccinated with a conjugated polysaccharide vaccine after the splenectomy, he was still susceptible to S. pneumoniae infection, because the isolated serovar (24F), a serovar long thought to be apathogenic, is not covered by any vaccine currently approved, neither a conjugated nor an unconjugated polysaccharide one.Conclusions: This case demonstrates that, due to presence of different serovars, also infections with bacteria against which patients are vaccinated have to be considered as differential diagnosis. Although vaccine development has extended the coverage of S. pneumoniae from 7 to 23 serovars within recent years, there is still demand for novel vaccines which can provide broader protection also against so-thought "apathogenic" strains, especially for groups at high risk. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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