Correction to: Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study
| العنوان: | Correction to: Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study |
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| المؤلفون: | Christophe Vinsonneau, Dimitri Titeca-Beauport, Momar Diouf, Ly Van Phach Vong, Cédric Bruel, Delphine Daubin, Guillaume Belliard, Maud Andrieu, Karim Chaoui, Sami Alaya, Julien Maizel, Isabelle Rouquette-Vincenti, Frederic Godde, Michel Pascal, Kada Klouche |
| المصدر: | Critical Care Critical Care, Vol 24, Iss 1, Pp 1-2 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Urology, Urine, Critical Care and Intensive Care Medicine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Recovery, Predictive Value of Tests, Septic shock, medicine, Humans, Prospective Studies, Creatinine, Tissue Inhibitor of Metalloproteinase-2, Receiver operating characteristic, business.industry, Research, Curve analysis, Acute kidney injury, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Correction, 030208 emergency & critical care medicine, lcsh:RC86-88.9, Cell Cycle Checkpoints, Acute Kidney Injury, Middle Aged, medicine.disease, Shock, Septic, Insulin-Like Growth Factor Binding Proteins, Intensive Care Units, Logistic Models, chemistry, Multicenter study, ROC Curve, Area Under Curve, Female, France, business, Early phase, Biomarkers |
| الوصف: | Background The urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting and stratifying AKI. In this study, we analyzed the utility of these biomarkers for distinguishing between transient and persistent AKI in the early phase of septic shock. Methods We performed a prospective, multicenter study in 11 French ICUs. Patients presenting septic shock, with the development of AKI within the first 6 h, were included. Urine [TIMP-2]*[IGFBP7] was determined at inclusion (0 h), 6 h, 12 h, and 24 h. AKI was considered transient if it resolved within 3 days. Discriminative power was evaluated by receiver operating characteristic (ROC) curve analysis. Results We included 184 patients, within a median [IQR] time of 1.0 [0.0–3.0] h after norepinephrine (NE) initiation; 100 (54%) patients presented transient and 84 (46%) presented persistent AKI. Median [IQR] baseline urine [TIMP-2]*[IGFBP7] was higher in the persistent AKI group (2.21 [0.81–4.90] (ng/ml)2/1000) than in the transient AKI group (0.75 [0.20–2.12] (ng/ml)2/1000; p |
| اللغة: | English |
| تدمد: | 1466-609X 1364-8535 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76f15a323d682e4beaa20c4756f1f22Test http://europepmc.org/articles/PMC7401189Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e76f15a323d682e4beaa20c4756f1f22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1466609X 13648535 |
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