Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
| العنوان: | Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing |
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| المؤلفون: | Asim Bikas Das |
| المصدر: | BMC Medical Genomics BMC Medical Genomics, Vol 14, Iss 1, Pp 1-14 (2021) |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Lung Diseases, Gene regulatory network, Disease, Comorbidity, QH426-470, Bioinformatics, Antiviral Agents, Disease network, Lung Disorder, Drug Discovery, Genetics, Medicine, Humans, Gene Regulatory Networks, Protein Interaction Maps, Internal medicine, Pandemics, Genetics (clinical), Repurposing, Host Microbial Interactions, business.industry, SARS-CoV-2, Systems Biology, Drug Repositioning, COVID-19, respiratory system, medicine.disease, RC31-1245, Human genetics, respiratory tract diseases, COVID-19 Drug Treatment, Drug repositioning, Drug development, Lung disease, business, Algorithms, Research Article |
| الوصف: | Background Higher mortality of COVID-19 patients with lung disease is a formidable challenge for the health care system. Genetic association between COVID-19 and various lung disorders must be understood to comprehend the molecular basis of comorbidity and accelerate drug development. Methods Lungs tissue-specific neighborhood network of human targets of SARS-CoV-2 was constructed. This network was integrated with lung diseases to build a disease–gene and disease-disease association network. Network-based toolset was used to identify the overlapping disease modules and drug targets. The functional protein modules were identified using community detection algorithms and biological processes, and pathway enrichment analysis. Results In total, 141 lung diseases were linked to a neighborhood network of SARS-CoV-2 targets, and 59 lung diseases were found to be topologically overlapped with the COVID-19 module. Topological overlap with various lung disorders allows repurposing of drugs used for these disorders to hit the closely associated COVID-19 module. Further analysis showed that functional protein–protein interaction modules in the lungs, substantially hijacked by SARS-CoV-2, are connected to several lung disorders. FDA-approved targets in the hijacked protein modules were identified and that can be hit by exiting drugs to rescue these modules from virus possession. Conclusion Lung diseases are clustered with COVID-19 in the same network vicinity, indicating the potential threat for patients with respiratory diseases after SARS-CoV-2 infection. Pathobiological similarities between lung diseases and COVID-19 and clinical evidence suggest that shared molecular features are the probable reason for comorbidity. Network-based drug repurposing approaches can be applied to improve the clinical conditions of COVID-19 patients. |
| اللغة: | English |
| تدمد: | 1755-8794 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8454db5fd199edd82865de6324eac2Test http://europepmc.org/articles/PMC8447809Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe8454db5fd199edd82865de6324eac2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17558794 |
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