Comparison of rapid immunoassays for rupture of fetal membranes
| العنوان: | Comparison of rapid immunoassays for rupture of fetal membranes |
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| المؤلفون: | Cheri Johnson, Irogue Igbinosa, Jon E. Block, Ferney A. Moore |
| المصدر: | BMC Pregnancy and Childbirth BMC Pregnancy and Childbirth, Vol 17, Iss 1, Pp 1-5 (2017) |
| بيانات النشر: | BioMed Central, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Fetal Membranes, Premature Rupture, Amniotic fluid, Time Factors, Concordance, Gestational Age, Placental alpha microglobulin-1 (PAMG-1), lcsh:Gynecology and obstetrics, Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Pregnancy, Prenatal Diagnosis, medicine, Fetal distress, Rupture of membranes, Point of care immunoassay, Humans, 030212 general & internal medicine, Prospective Studies, lcsh:RG1-991, Retrospective Studies, Immunoassay, 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, Obstetrics, business.industry, Premature rupture of membranes, Obstetrics and Gynecology, Gestational age, ROM plus®, Insulin-like growth factor binding protein (IGFBP-1), medicine.disease, Surgery, Amnisure®, Female, Alpha-fetoprotein (AFP), business, Research Article |
| الوصف: | Background Rupture of membranes (ROM) before the onset of uterine contractions, particularly in pregnancies less than 37 weeks gestational age, is a common diagnostic problem in obstetrical practice. Timely detection of ROM is vital to support gestational age-specific interventions to optimize perinatal outcomes and minimize the risk of serious complications such as preterm delivery, fetal distress and maternal/fetal infections. Rapid bedside immunoassay tests designed to detect amniotic fluid proteins in cervicovaginal fluids have emerged as valuable clinical tools to provide timely ROM diagnosis. Methods In this prospective observational study, two commercially-available immunoassay tests (ROM Plus®, AmniSure®) were evaluated concurrently in 111 pregnant women who presented with the chief complaint of ROM. Immunoassay results were compared to clinical parameters for determining ROM via comprehensive, retrospective clinical chart review. Diagnostic performance characteristics were calculated including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy. Results Overall, diagnostic performance characteristics were robust and similar between ROM Plus® and AmniSure®, respectively: sensitivity (96.4 and 89.3%), specificity (98.8 and 100%), PPV (96.4 and 100%), NPV (98.8% and 96.5) and accuracy (98.2 and 97.3%). For term patients (≥37 weeks gestation), the sensitivities were 93.8 and 81.3% and specificities were 97.1 and 100% for ROM Plus® and AmniSure®, respectively. For preterm patients ( |
| اللغة: | English |
| تدمد: | 1471-2393 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeea3851b89928a2250ae6798edf4cb2Test http://europepmc.org/articles/PMC5406884Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aeea3851b89928a2250ae6798edf4cb2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712393 |
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