التفاصيل البيبلوغرافية
| العنوان: |
Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly |
| المؤلفون: |
Kim, Soonok, Cho, Yun Sung, Kim, Hak-Min, Chung, Oksung, Kim, Hyunho, Jho, Sungwoong, Seomun, Hong, Kim, Jeongho, Bang, Woo Young, Kim, Changmu, An, Junghwa, Bae, Chang Hwan, Bhak, Youngjune, Jeon, Sungwon, Yoon, Hyejun, Kim, Yumi, Jun, JeHoon, Lee, HyeJin, Cho, Suan, Uphyrkina, Olga, Kostyria, Aleksey, Goodrich, John, Miquelle, Dale, Roelke, Melody, Lewis, John, Yurchenko, Andrey, Bankevich, Anton, Cho, Juok, Lee, Semin, Edwards, Jeremy S., Weber, Jessica A., Cook, Jo, Kim, Sangsoo, Lee, Hang, Manica, Andrea, Lee, Ilbeum, O’Brien, Stephen J., Bhak, Jong, Yeo, Joo-Hong |
| المساهمون: |
김순옥, 조윤성, 김학민, 정옥성, 김현호, 조성웅, 서문홍, 김정호, 방우영, 김창무, 안정화, 배창환, 박영준, 전성원, 윤혜준, 김유미, 전제훈, 이혜진, 조주옥, 이세민, 김상수, 이항, 이일범, 박종, 여주홍 |
| بيانات النشر: |
BioMed Central |
| سنة النشر: |
2016 |
| المجموعة: |
Seoul National University: S-Space |
| مصطلحات موضوعية: |
Carnivorous diet, Evolutionary adaptation, Leopard, Felidae, De novo assembly, Comparative genomics |
| الوصف: |
Background There are three main dietary groups in mammals: carnivores, omnivores, and herbivores. Currently, there is limited comparative genomics insight into the evolution of dietary specializations in mammals. Due to recent advances in sequencing technologies, we were able to perform in-depth whole genome analyses of representatives of these three dietary groups. Results We investigated the evolution of carnivory by comparing 18 representative genomes from across Mammalia with carnivorous, omnivorous, and herbivorous dietary specializations, focusing on Felidae (domestic cat, tiger, lion, cheetah, and leopard), Hominidae, and Bovidae genomes. We generated a new high-quality leopard genome assembly, as well as two wild Amur leopard whole genomes. In addition to a clear contraction in gene families for starch and sucrose metabolism, the carnivore genomes showed evidence of shared evolutionary adaptations in genes associated with diet, muscle strength, agility, and other traits responsible for successful hunting and meat consumption. Additionally, an analysis of highly conserved regions at the family level revealed molecular signatures of dietary adaptation in each of Felidae, Hominidae, and Bovidae. However, unlike carnivores, omnivores and herbivores showed fewer shared adaptive signatures, indicating that carnivores are under strong selective pressure related to diet. Finally, felids showed recent reductions in genetic diversity associated with decreased population sizes, which may be due to the inflexible nature of their strict diet, highlighting their vulnerability and critical conservation status. Conclusions Our study provides a large-scale family level comparative genomic analysis to address genomic changes associated with dietary specialization. Our genomic analyses also provide useful resources for diet-related genetic and health research. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
Genome Biology, 17(1):211; http://hdl.handle.net/10371/109880Test |
| الإتاحة: |
http://hdl.handle.net/10371/109880Test |
| حقوق: |
The Author(s). |
| رقم الانضمام: |
edsbas.F24B1CCF |
| قاعدة البيانات: |
BASE |
