A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer
| العنوان: | A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer |
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| المؤلفون: | Emanuele Damiano Luca Urso, Angela Grassi, Claudia Mescoli, Sofia Tessarollo, Lisa Perilli, Massimo Rugge, Matteo Fassan, Laura Albertoni, Paola Zanovello |
| المصدر: | Molecular Cancer Molecular Cancer, Vol 17, Iss 1, Pp 1-5 (2018) |
| بيانات النشر: | BioMed Central, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Colorectal cancer, Tumor resection, Biology, lcsh:RC254-282, Resection, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Internal medicine, microRNA, medicine, Adjuvant therapy, Humans, Postoperative Period, Stage (cooking), Intestinal Mucosa, Letter to the Editor, Adjacent mucosa, Localized colon cancer, MicroRNAs, Predictive markers, Relapse, Molecular Medicine, Predictive biomarker, adjacent mucosa, Neoplasm Staging, relapse, localized colon cancer, predictive markers, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, microRNAs, Gene Expression Regulation, Neoplastic, 030104 developmental biology, ROC Curve, 030220 oncology & carcinogenesis, Colonic Neoplasms, Curative surgery, RNA Interference |
| الوصف: | Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high risk of relapse after curative treatment is presently available. Forty-eight localized (i.e. stage I-II) colon cancer patients who underwent radical tumor resection were considered. The expression of five miRNAs, involved in CRC progression, was investigated by qRT-PCR in both tumor tissue and matched normal colon mucosa. Interestingly, we found that the coordinate deregulation of four miRNAs (i.e. miR-18a, miR-21, miR-182 and miR-183), evaluated in the normal mucosa adjacent to tumor, is predictive of relapse within 55 months from curative surgery. Our results, if confirmed in independent studies, may help to identify high-risk patients who could benefit most from adjuvant therapy. Moreover, this work highlights the importance of extending the search for tissue biomarkers also to the tumor-adjacent mucosa. Electronic supplementary material The online version of this article (10.1186/s12943-018-0770-8) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 1476-4598 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7157476d77a3fc0ce830fc8d7925f21aTest http://europepmc.org/articles/PMC5791208Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7157476d77a3fc0ce830fc8d7925f21a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764598 |
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