Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review
| العنوان: | Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review |
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| المؤلفون: | László Sztriha, Johann Sellner, Eva C. Schulte, Raffaele Nardone, Slaven Pikija, Larissa Hauer |
| المصدر: | Journal of Neuroinflammation Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019) |
| بيانات النشر: | BioMed Central, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Vasculitis, Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Immunology, Infarction, Vasculopathy, lcsh:RC346-429, Temporal lobe, Brain ischemia, 03 medical and health sciences, Cellular and Molecular Neuroscience, Young Adult, 0302 clinical medicine, Hematoma, Herpes simplex virus encephalitis, medicine, Animals, Humans, Cerebral venous sinus thrombosis, Mortality, Child, lcsh:Neurology. Diseases of the nervous system, Aged, Intracerebral hemorrhage, business.industry, General Neuroscience, Research, Infant, Herpes Simplex, Middle Aged, medicine.disease, Cerebrovascular complications, ddc, Cerebrovascular Disorders, 030104 developmental biology, Neurology, Child, Preschool, Central Nervous System Viral Diseases, Ischemic stroke intracerebral hemorrhage, Female, business, 030217 neurology & neurosurgery, Cerebral vasculitis |
| الوصف: | Background Intracerebral hemorrhage and ischemic stroke are increasingly recognized complications of central nervous system (CNS) infection by herpes simplex virus (HSV). Aim of the study To analyze clinical, imaging, and laboratory findings and outcomes of cerebrovascular manifestations of HSV infection. Methods Systematic literature review from January 2000 to July 2018. Results We identified 38 patients (median age 45 years, range 1–73) comprising 27 cases of intracerebral hemorrhage, 10 of ischemic stroke, and 1 with cerebral venous sinus thrombosis. Intracerebral hemorrhage was predominantly (89%) a complication of HSV encephalitis located in the temporal lobe. Hematoma was present on the first brain imaging in 32%, and hematoma evacuation was performed in 30% of these cases. Infarction was frequently multifocal, and at times preceded by hemorrhage (20%). Both a stroke-like presentation and presence of HSV encephalitis in a typical location were rare (25% and 10%, respectively). There was evidence of cerebral vasculitis in 63%, which was exclusively located in large-sized vessels. Overall mortality was 21% for hemorrhage and 0% for infarction. HSV-1 was a major cause of hemorrhagic complications, whereas HSV-2 was the most prevalent agent in the ischemic manifestations. Conclusion We found a distinct pathogenesis, cause, and outcome for HSV-related cerebral hemorrhage and infarction. Vessel disruption within a temporal lobe lesion caused by HSV-1 is the presumed mechanism for hemorrhage, which may potentially have a fatal outcome. Brain ischemia is mostly related to multifocal cerebral large vessel vasculitis associated with HSV-2, where the outcome is more favorable. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1742-2094 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa13e3b04b0420274ec6f6a3802d77aTest http://europepmc.org/articles/PMC6352343Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2fa13e3b04b0420274ec6f6a3802d77a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17422094 |
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