التفاصيل البيبلوغرافية
| العنوان: |
Application of the Immunoscore as prognostic tool for hepatocellular carcinoma |
| المؤلفون: |
Annacarmen Petrizzo, Luigi Buonaguro |
| المصدر: |
Journal for Immunotherapy of Cancer |
| بيانات النشر: |
BioMed Central, 2016. |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
0301 basic medicine, Oncology, Male, Cancer Research, CD3 Complex, Colorectal cancer, Hepatocellular carcinoma, Kaplan-Meier Estimate, Programmed Death Ligand 1 (PD-L1), CD8-Positive T-Lymphocytes, Tumor-infiltrating lymphocytes, B7-H1 Antigen, Metastasis, 0302 clinical medicine, Recurrence, Risk Factors, T-Lymphocyte Subsets, Immunology and Allergy, Stage (cooking), Cancer immunology, Aged, 80 and over, Liver Neoplasms, Middle Aged, Prognosis, Primary tumor, 3. Good health, Neoplasm Proteins, 030220 oncology & carcinogenesis, Molecular Medicine, Female, Adult, medicine.medical_specialty, Carcinoma, Hepatocellular, Immunoscore, Immunology, Article, TNM Stage, Disease-Free Survival, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Internal medicine, medicine, Biomarkers, Tumor, Humans, Neoplasm Invasiveness, Aged, Neoplasm Staging, Pharmacology, business.industry, Cancer, medicine.disease, Patient Outcome Assessment, 030104 developmental biology, Commentary, business, Biomarkers, Follow-Up Studies |
| الوصف: |
Immune cells that infiltrate a tumor may be a prognostic factor for patients who have had surgically resected hepatocellular carcinoma (HCC). The density of intratumoral total (CD3(+)) and cytotoxic (CD8(+)) T lymphocytes was measured in the tumor interior and in the invasive margin of 65 stage I to IV HCC tissue specimens from a single cohort. Immune cell density in the interior and margin was converted to a binary score (0, low; 1, high), which was correlated with tumor recurrence and relapse-free survival (RFS). In addition, the expression of programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) was correlated with the density of CD3(+) and CD8(+) cells and clinical outcome. High densities of both CD3(+) and CD8(+) T cells in both the interior and margin, along with corresponding Immunoscores, were significantly associated with a low rate of recurrence (P = 0.007) and a prolonged RFS (P = 0.002). In multivariate logistic regression models adjusted for vascular invasion and cellular differentiation, both CD3(+) and CD8(+) cell densities predicted recurrence, with odds ratios of 5.8 [95% confidence interval (CI), 1.6-21.8] for CD3(+) and 3.9 (95% CI, 1.1-14.1) for CD8(+) Positive PD-L1 staining was correlated with high CD3 and CD8 density (P = 0.024 and 0.005, respectively) and predicted a lower rate of recurrence (P = 0.034), as well as prolonged RFS (P = 0.029). Immunoscore and PD-L1 expression, therefore, are useful prognostic markers in patients with HCC who have undergone primary tumor resection. Cancer Immunol Res; 4(5); 419-30. ©2016 AACR. |
| اللغة: |
English |
| تدمد: |
2051-1426 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00dd70bf973dd0f5ab55976dc2a8080Test
http://europepmc.org/articles/PMC5109780Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....f00dd70bf973dd0f5ab55976dc2a8080 |
| قاعدة البيانات: |
OpenAIRE |
