دورية أكاديمية
Positive Results of Serum Galactomannan Assays and Pulmonary Computed Tomography Predict the Higher Response Rate of Empirical Antifungal Therapy in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
| العنوان: | Positive Results of Serum Galactomannan Assays and Pulmonary Computed Tomography Predict the Higher Response Rate of Empirical Antifungal Therapy in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation |
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| المؤلفون: | Ji, Yu, Xu, Lan-ping, Liu, Dai-hong, Chen, Yu-hong, Han, Wei, Zhang, Xiao-hui, Chen, Huan, Wang, Yu, Wang, Jing-zhi, Liu, Kai-yan, Huang, Xiao-jun |
| المساهمون: | Huang, XJ (reprint author), Peking Univ, Inst Hematol, 11 Zizhimen South St, Beijing 100044, Peoples R China., Peking Univ, Inst Hematol, Beijing 100044, Peoples R China., Peking Univ, Inst Hematol, 11 Zizhimen South St, Beijing 100044, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | biology of blood and marrow transplantation |
| سنة النشر: | 2011 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Galactomannan, Empirical antifungal therapy, Invasive aspergillosis, Allogeneic hematopoietic stem cell transplant, INVASIVE FUNGAL-INFECTION, NEUTROPENIC PATIENTS, PERSISTENT FEVER, AMPHOTERICIN-B, HIGH-RISK, ASPERGILLOSIS, RECIPIENTS, DIAGNOSIS, EPIDEMIOLOGY, GUIDELINES |
| الوصف: | Invasive fungal disease (IFD) is a leading cause of infection-related mortality among patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the mortality of IFD has been decreased with empirical antifungal therapy in this population, overtreatment remains a problem, for the persistent or recurrent fever is nonspecific for an IFD. Hence, we explored retrospectively the value of incorporating serum galactomannan (GM) test and pulmonary high-resolution computed tomography (HRCT) as predictors for higher response rate of empirical treatment. In our study, all of 124 patients after allo-HSCT received empirical antifungal therapy when the persistent or recurrent fever developed after receiving broad-spectrum antibiotics. Meanwhile, the levels of serum GM were monitored twice weekly and pulmonary HRCT was performed serially. It showed that the response rate of empirical antifungal therapy was higher in patients with positive results of serum GM tests and/or chest CT scan than that in all patients (66.1% versus 44.6%, P=.008). Moreover, only 10 of 55 patients with both negative GM tests and pulmonary HRCT responded to empirical treatment, and 7 of these 10 patients did not take antifungal agents for prophylaxis. It suggested that these 2 diagnostic tools could not predict patients without adequate Candida prophylaxis well. Thus, we concluded that serum GM assays and pulmonary CT scan could find out patients who really need empirical antifungal therapy, which resulted in improving the efficiency of the treatment. Biol Blood Marrow Transplant 17: 759-764 (2011) (C) 2011 American Society for Blood and Marrow Transplantation ; Hematology ; Immunology ; Transplantation ; SCI(E) ; PubMed ; 3 ; ARTICLE ; 5 ; 759-764 ; 17 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1083-8791 |
| العلاقة: | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION.2011,17,(5),759-764.; 666646; http://hdl.handle.net/20.500.11897/195508Test; WOS:000290061500022 |
| DOI: | 10.1016/j.bbmt.2010.11.002 |
| الإتاحة: | https://doi.org/20.500.11897/195508Test https://doi.org/10.1016/j.bbmt.2010.11.002Test https://hdl.handle.net/20.500.11897/195508Test |
| رقم الانضمام: | edsbas.8E6209C2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10838791 |
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| DOI: | 10.1016/j.bbmt.2010.11.002 |