دورية أكاديمية
HPV acting on E-cadherin, P53 and P16: Literature review
| العنوان: | HPV acting on E-cadherin, P53 and P16: Literature review |
|---|---|
| المؤلفون: | Ottria, L., Candotto, V., Cura, F., Baggi, L., Arcuri, C., Nardone, M., Gaudio, R. M., Gatto, R., Spadari, F., Carinci, F. |
| المساهمون: | Ottria, L, Candotto, V, Cura, F, Baggi, L, Arcuri, C, Nardone, M, Gaudio, Rm, Gatto, R, Spadari, F, Carinci, F |
| بيانات النشر: | Biolife s.a.s. IT |
| سنة النشر: | 2018 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | E-cadherin, Head squamous cell carcinoma, HPV, Oral, P16, P53, Endocrinology, Diabetes and Metabolism, Immunology and Allergy, Physiology, Immunology, Oncology, Physiology (medical), Cancer Research, Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE |
| الوصف: | In addition to tobacco and alcohol consumption, the two main risk factors for oral squamous cell carcinoma (OSCC), recent studies have revealed infections with human papilloma virus (HPV) as an additional risk factor for OSCC development. In the field of head and neck malignancies, the prevalence of HPV infections in oropharyngeal cancer (OC) ranges in different studies up to 84%. While HPV infection is discussed as an independent risk factor in this region, its distinguished role in carcinogenesis of tumours localized to the oral cavity remains uncertain. A systematic literature search was performed using PubMed, Cochrane library, Science Direct, and the Internet search, with language restricted to English. The search included published studies which dealt with detection methods of HPV-related oral and oropharyngeal cancers and biomolecular studies, particularly regarding the compromising of p53 p16 and e-cadherin’s. P53 Tumour suppressor protein p53 has several functions that are related to maintaining genomic stability and inhibiting cell proliferation in response to DNA damage. For preventing neoplasia to occur, the most important of these functions are cessation of cell growth and induction of either apoptosis or senescence. P16 is a cellular protein involved in cell cycle regulation. It is a cyclin-dependent kinase 4 (CDK4) inhibitor, and is integral to Rb mediated regulation of G1-S phase of the cell cycle. P16 is expressed at a very low level in normal cell as Rb inhibits transcription of p16. Various detection methods ranging from immunohistochemistry (IHC) to molecular techniques have been used to determine the HPV status of HNSCC. E-cadherin, a 120 kDa Type I classical cadherin, is expressed primarily on epithelial cells. It is found on the surface of keratinocytesand Langerhans cells (LC) and E-cadherin mediated adhesion between these cell types is required for LC retention in the epidermis. It is also an important tumour suppressor protein: its loss or inactivation is associated with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29460521; info:eu-repo/semantics/altIdentifier/wos/WOS:000426850900010; volume:32; issue:2; firstpage:73; lastpage:79; numberofpages:7; journal:JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS; http://hdl.handle.net/2108/209179Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85042303720; http://www.biolifesas.org/contentsJBRHA.htmTest |
| الإتاحة: | http://hdl.handle.net/2108/209179Test http://www.biolifesas.org/contentsJBRHA.htmTest |
| رقم الانضمام: | edsbas.FEA0EB61 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |