When Orexins Meet Cannabinoids: Bidirectional Functional Interactions
| العنوان: | When Orexins Meet Cannabinoids: Bidirectional Functional Interactions |
|---|---|
| المؤلفون: | África Flores, Fernando Berrendero, Patricia Robledo |
| المصدر: | DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria Universidad Francisco de Vitoria DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria instname Recercat. Dipósit de la Recerca de Catalunya |
| بيانات النشر: | Biochemical Pharmacology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Nociception, Food intake, medicine.medical_treatment, Biochemistry, Eating, 03 medical and health sciences, 0302 clinical medicine, Intracellular signaling pathways, Reward, mental disorders, medicine, Animals, Receptor, Cannabinoid, Pharmacology, Cannabinoides -- Efectes fisiològics, Orexins, Cannabinoids, Chemistry, Feeding, digestive, oral, and skin physiology, Brain, Endocannabinoid system, Orexin receptor, Orexin, Heterodimers, 030104 developmental biology, nervous system, lipids (amino acids, peptides, and proteins), Neuroscience, 030217 neurology & neurosurgery, psychological phenomena and processes, Endocannabinoids |
| الوصف: | A growing body of evidence suggests the existence of biochemical and functional interactions between the endocannabinoid and orexin systems. Cannabinoid and orexin receptors have been shown to form heterodimers in agreement with the overlapping distribution of both receptors in several brain areas, and the activation of common intracellular signaling pathways, such as the MAP kinase cascade. The activation of orexin receptors induces the synthesis of the endocannabinoid 2-arachidonoyl glycerol suggesting that the endocannabinoid system participates in some physiological functions of orexins. Indeed, functional interactions between these two systems have been demonstrated in several behavioral responses including nociception, reward and food intake. The present review is focused on the latest developments in cannabinoid-orexin cross-modulation and the implications of this interesting interaction. This work was supported by Instituto de Salud Carlos III (PI14/00210),the Fundació la Marató de TV3 (231/C/2014) to PR,“Plan Nacional sobre Drogas”(#2014I019) and “Ministerio de Economía y Competitividad”(SAF2017-85299-R) to FB, and the Catalunya Government AGAUR (2017SGR210). We would like to thank Carla Ramón Duaso for her help with reference editing. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0d1fb4590aa6185880467f52eb50c7Test http://hdl.handle.net/10641/1533Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ca0d1fb4590aa6185880467f52eb50c7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |