دورية أكاديمية
Acetyl-L-carnitine and Amyotrophic Lateral Sclerosis: Current Evidence and Potential use
| العنوان: | Acetyl-L-carnitine and Amyotrophic Lateral Sclerosis: Current Evidence and Potential use |
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| المؤلفون: | De Marchi, Fabiola, Venkatesan, Sakthipriyan, Saraceno, Massimo, Mazzini, Letizia, Grossini, Elena |
| المصدر: | CNS & Neurological Disorders - Drug Targets ; volume 23, issue 5, page 588-601 ; ISSN 1871-5273 |
| بيانات النشر: | Bentham Science Publishers Ltd. |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Pharmacology, General Neuroscience |
| الوصف: | Background: The management of neurodegenerative diseases can be frustrating for clinicians, given the limited progress of conventional medicine in this context. Aim: For this reason, a more comprehensive, integrative approach is urgently needed. Among various emerging focuses for intervention, the modulation of central nervous system energetics, oxidative stress, and inflammation is becoming more and more promising. Methods: In particular, electrons leakage involved in the mitochondrial energetics can generate reactive oxygen-free radical-related mitochondrial dysfunction that would contribute to the etiopathology of many disorders, such as Alzheimer's and other dementias, Parkinson's disease, multiple sclerosis, stroke, and amyotrophic lateral sclerosis (ALS). Results: In this context, using agents, like acetyl L-carnitine (ALCAR), provides mitochondrial support, reduces oxidative stress, and improves synaptic transmission. Conclusion: This narrative review aims to update the existing literature on ALCAR molecular profile, tolerability, and translational clinical potential use in neurodegeneration, focusing on ALS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2174/1871527322666230330083757 |
| الإتاحة: | https://doi.org/10.2174/1871527322666230330083757Test https://www.eurekaselect.com/215163/articleTest |
| رقم الانضمام: | edsbas.F6F8E05C |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1871527322666230330083757 |
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