Metabolic therapy: Lessons from liver diseases
| العنوان: | Metabolic therapy: Lessons from liver diseases |
|---|---|
| المؤلفون: | Montserrat Marí, José C. Fernández-Checa, Albert Morales, Anna Colell, Carmen García-Ruiz |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname Scopus-Elsevier |
| بيانات النشر: | Bentham Science Publishers, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | medicine.medical_specialty, Ceramide, Apoptosis, Biology, Proinflammatory cytokine, chemistry.chemical_compound, Insulin resistance, Fibrosis, Internal medicine, Drug Discovery, medicine, Animals, Humans, Molecular Targeted Therapy, Pharmacology, Sphingolipids, Lipogenesis, Fatty liver, Endoplasmic Reticulum Stress, medicine.disease, Sphingolipid, Mitochondria, Fatty Liver, Cholesterol, Endocrinology, chemistry, Tumor Necrosis Factors, Cancer research, Insulin Resistance, Steatosis, Steatohepatitis, Fatty Liver, Alcoholic |
| الوصف: | Fatty liver disease is one of most prevalent metabolic liver diseases, which includes alcoholic (ASH) and nonalcoholic steatohepatitis (NASH). Its initial stage is characterized by fat accumulation in the liver, that can progress to steatohepatitis, a stage of the disease in which steatosis is accompanied by inflammation, hepatocellular death, oxidative stress and fibrosis. Recent evidence in experimental models as well as in patients with steatohepatitis have uncovered a role for cholesterol and sphingolipids, particularly ceramide, in the transition from steatosis to steatohepatitis, insulin resistance and hence disease progression. Cholesterol accumulation and its trafficking to mitochondria sensitizes fatty liver to subsequent hits including inflammatory cytokines, such as TNF/Fas, in a pathway involving ceramide generation by acidic sphingomyelinase (ASMase). Thus, targeting both cholesterol and/or ASMase may represent a novel therapeutic approach of relevance in ASH and NASH, two of the most common forms of liver diseases worldwide. © 2011 Bentham Science Publishers. The work was supported by grants SAF2008-02199, SAF2008-04974, SAF2008-04800 and SAF2009-11417 (Plan Nacional de I+D), by CIBEREHD from the Instituto Carlos III, the Fundacion Mutua Madrilena, the center grant P50AA11999 (Southern California Research Center for ALPD and Cirrhosis) from the National Institute on Alcohol Abuse and Alcoholism of NIH, USA, and Fundacio La Marato de TV3. This work was carried out (in part) at the Esther Koplowitz Centre. |
| اللغة: | English |
| تدمد: | 1381-6128 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51e49f4351ad703b2712bfc4b077c93Test http://hdl.handle.net/10261/78637Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a51e49f4351ad703b2712bfc4b077c93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13816128 |
|---|