المؤلفون: Von Keudell, Arvind G., Thornhill, Thomas S., Katz, Jeffrey N., Losina, Elena

مصطلحات موضوعية: Clopidogrel, Coronary stenting, Mortality, Plavix, Revision total knee arthroplasty, Total knee arthroplasty

الوصف: Background: The optimal antiplatelet therapy (APT) treatment strategy after Coronary Artery Stenting (CAS) in non-cardiac surgery, such as total knee arthroplasty (TKA) or urgent TKA-related surgery remains unknown. Methods: We built a decision tree model to examine the mortality outcomes of two alternative strategies for APT after CAS use in the perioperative period namely, continuous use and discontinuation. Results: If surgery was performed in the first month after CAS placement, discontinuing APT led to an estimated 30-day post TKA mortality of 10.5%, compared to 1.0% in a strategy with continuous APT use. Mortality with both strategies decreased with longer intervals. Conclusion: Our model demonstrated that APT discontinuation in patients undergoing TKA or urgent TKA related surgery after CAS placement might lead to greater 30-day mortality up to one year. ; Version of Record

وصف الملف: application/pdf

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220172/pdfTest/; The Open Orthopaedics Journal; Von Keudell, Arvind G., Thomas S. Thornhill, Jeffrey N. Katz, and Elena Losina. 2016. “Mortality Risk Assessment of Total Knee Arthroplasty and Related Surgery After Percutaneous Coronary Intervention.” The Open Orthopaedics Journal 10 (1): 706-716. doi:10.2174/1874325001610010706. http://dx.doi.org/10.2174/1874325001610010706Test.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:30371160Test

الإتاحة: https://doi.org/10.2174/1874325001610010706Test
http://nrs.harvard.edu/urn-3:HUL.InstRepos:30371160Test

المؤلفون: Schwarzkopf, Ran, Mikhael, Bassem, Wright, Elizabeth, Estok, Daniel M, Katz, Jeffrey N

مصطلحات موضوعية: Hip arthroplasty, modular antibiotic cement spacer, periprosthetic infection, two-stage revision surgery

الوصف: Two-stage revision has been shown to be the most successful treatment in eradicating deep infection following total hiparthroplasty. We identified 62 patients treated by a two-stage revision. We defined “successful revision” as negative intraoperative cultures and no further infection-related procedure. We defined “eradication of infection” on the basis of negative cultures and clinical diagnosis at least one year after 2nd stage procedure. After a mean follow up of 2.7 years, eradication of the infection was documented in 91.1%, and a successful two-stage revision in 85.7% of patients. We observed no association between higher pre-reimplantation levels of ESR and C-reactive protein and lower likelihood of successful two-stage revision. We found an association between a history of another previous infected prosthetic joint and a failed 2nd stage procedure. Failure to achieve eradication of infection and successful two-stage revision occurs infrequently. Patients with prior history of a previous prosthetic joint infection are at higher risk of failure. ; Version of Record

وصف الملف: application/pdf

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066371/pdfTest/; The Open Orthopaedics Journal; Schwarzkopf, Ran, Bassem Mikhael, Elizabeth Wright, Daniel M Estok, and Jeffrey N Katz. 2014. “Treatment Failure Among Infected Periprosthetic Total Hip Arthroplasty Patients.” The Open Orthopaedics Journal 8 (1): 118-124. doi:10.2174/1874325020140515002. http://dx.doi.org/10.2174/1874325020140515002Test.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406577Test

الإتاحة: https://doi.org/10.2174/1874325020140515002Test
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406577Test