المؤلفون: Eloïse Equy, Jordana Hirtzel, Sophie Hellé, Béatrice Heurtault, Eric Mathieu, Morgane Rabineau, Vincent Ball, Lydie Ploux

المصدر: Beilstein Journal of Nanotechnology, Vol 14, Iss 1, Pp 1208-1224 (2023)

مصطلحات موضوعية: accumulation, albumin, antibacterial, escherichia coli, fluorescence, nanoparticles, penetration, polydopamine, Technology, Chemical technology, TP1-1185, Science, Physics, QC1-999

الوصف: Inspired by the eumelanin aggregates in human skin, polydopamine nanoparticles (PDA NPs) are promising nanovectors for biomedical applications, especially because of their biocompatibility. We synthesized and characterized fluorescent PDA NPs of 10–25 nm diameter based on a protein containing a lysine–glutamate diad (bovine serum albumin, BSA) and determined whether they can penetrate and accumulate in bacterial cells to serve as a marker or drug nanocarrier. Three fluorescent PDA NPs were designed to allow for tracking in three different wavelength ranges by oxidizing BSA/PDA NPs (Ox-BSA/PDA NPs) or labelling with fluorescein 5-isothiocyanate (FITC-BSA/PDA NPs) or rhodamine B isothiocyanate (RhBITC-BSA/PDA NPs). FITC-BSA/PDA NPs and RhBITC-BSA/PDA NPs penetrated and accumulated in both cell wall and inner compartments of Escherichia coli (E. coli) cells. The fluorescence signals were diffuse or displayed aggregate-like patterns with both labelled NPs and free dyes. RhBITC-BSA/PDA NPs led to the most intense fluorescence in cells. Penetration and accumulation of NPs was not accompanied by a bactericidal or inhibitory effect of growth as demonstrated with the Gram-negative E. coli species and confirmed with a Gram-positive bacterial species (Staphylococcus aureus). Altogether, these results allow us to envisage the use of labelled BSA/PDA NPs to track bacteria and carry drugs in the core of bacterial cells.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2190-4286Test

الوصول الحر: https://doaj.org/article/bd2618ca21354bb4abf693465dff2558Test

المؤلفون: Boris N. Khlebtsov, Andrey M. Burov, Timofey E. Pylaev, Nikolai G. Khlebtsov

المصدر: Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 794-803 (2019)

مصطلحات موضوعية: Au nanorods, cancer theranostics, fluorescent bioimaging, folate, polydopamine, targeted phototherapy, Technology, Chemical technology, TP1-1185, Science, Physics, QC1-999

الوصف: Au nanorods (AuNRs) have attracted a great interest as a platform for constructing various composite core/shell nanoparticles for theranostics applications. However, the development of robust methods for coating AuNRs with a biocompatible shell of high loading capacity and with functional groups still remains challenging. Here, we coated AuNRs with a polydopamine (PDA) shell and functionalized AuNR-PDA particles with folic acid and rhodamine 123 (R123) to fabricate AuNR-PDA-R123-folate nanocomposites. To the best of our knowledge, such AuNR-PDA-based composites combining fluorescent imaging and plasmonic phothothermal abilities have not been reported previously. The multifunctional nanoparticles were stable in cell buffer, nontoxic and suitable for targeted fluorescent imaging and photothermal therapy of cancer cells. We demonstrate the enhanced accumulation of folate-functionalized nanoparticles in folate-positive HeLa cells in contrast to the folate-negative HEK 293 cells using fluorescent microscopy. The replacement of folic acid with polyethylene glycol (PEG) leads to a decrease in nanoparticle uptake by both folate-positive and folate-negative cells. We performed NIR light-mediated targeted phototherapy using AuNR-PDA-R123-folate and obtained a remarkable cancer cell killing efficiency in vitro in comparison with only weak-efficient nontargeted PEGylated nanoparticles. Our work illustrates that AuNR-PDA could be a promising nanoplatform for multifunctional tumor theranostics in the future.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2190-4286Test

الوصول الحر: https://doaj.org/article/2548a3dff22d4a3c9a7a40c399c69926Test

المؤلفون: Can Zhao, Yuexiao Song, Tianyu Xiang, Wenxiu Qu, Shuo Lou, Xiaohong Yin, Feng Xin

المصدر: Beilstein Journal of Nanotechnology, Vol 9, Iss 1, Pp 1770-1781 (2018)

مصطلحات موضوعية: absorbent regeneration, CoAl layered double hydroxide, efficient adsorbent, hexagonal nanoplates, magnetic nanoparticles, polydopamine, Technology, Chemical technology, TP1-1185, Science, Physics, QC1-999

الوصف: Novel hexagonal nanoplates (NPLs) comprised of mesoporous carbon containing imbedded magnetic Co nanoparticles (CoAl2O4 phase) are prepared through direct carbonization of polydopamine (PDA)-coated CoAl layered double hydroxide (LDH). A uniform PDA coating initially covers the surface of LDH by dopamine self-polymerization under mild conditions. Well-dispersed Co nanoparticles are formed in the NPLs by the partial reduction of cobalt from Co2+ to Co0 with surface carbon during the heat treatment process. The surface morphology and specific surface area of the as-prepared NPLs can be tailored by adjusting the initial dopamine concentration and carbonization temperature. The mesoporous NPLs exhibit excellent sorption of rhodamine B (RhB) dye and fast magnetic separation in aqueous solution. Over 95% of RhB can be adsorbed within 2 min and the adsorption reaches equilibrium after about 30 min. The maximum adsorption capacity approaches 172.41 mg/g. After regeneration, this adsorbent can be recycled easily by magnetic separation and still possess good adsorption capacity for RhB removal, even after five cycles.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2190-4286Test

الوصول الحر: https://doaj.org/article/813200e77ae54f87aeb43f7134cdecbdTest

المؤلفون: Błażej Scheibe, Radosław Mrówczyński, Natalia Michalak, Karol Załęski, Michał Matczak, Mateusz Kempiński, Zuzanna Pietralik, Mikołaj Lewandowski, Stefan Jurga, Feliks Stobiecki

المصدر: Beilstein Journal of Nanotechnology, Vol 9, Iss 1, Pp 591-601 (2018)

مصطلحات موضوعية: aerogel, composite, Fe3O4 nanoparticles, polydopamine, reduced graphene oxide, Technology, Chemical technology, TP1-1185, Science, Physics, QC1-999

الوصف: Reduced graphene oxide–magnetite hybrid aerogels attract great interest thanks to their potential applications, e.g., as magnetic actuators. However, the tendency of magnetite particles to migrate within the matrix and, ultimately, escape from the aerogel structure, remains a technological challenge. In this article we show that coating magnetite particles with polydopamine anchors them on graphene oxide defects, immobilizing the particles in the matrix and, at the same time, improving the aerogel structure. Polydopamine coating does not affect the magnetic properties of magnetite particles, making the fabricated materials promising for industrial applications.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2190-4286Test

الوصول الحر: https://doaj.org/article/6cabb41b0929499bb5fe63e25c69c47aTest

المؤلفون: Karol Załęski, M. Matczak, N. Michalak, Zuzanna Pietralik, Feliks Stobiecki, Stefan Jurga, Mateusz Kempiński, Błażej Scheibe, Mikołaj Lewandowski, Radosław Mrówczyński

المصدر: Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology, Vol 9, Iss 1, Pp 591-601 (2018)

مصطلحات موضوعية: Materials science, Composite number, aerogel, Oxide, General Physics and Astronomy, Anchoring, Nanotechnology, 02 engineering and technology, engineering.material, 010402 general chemistry, lcsh:Chemical technology, 01 natural sciences, lcsh:Technology, reduced graphene oxide, Full Research Paper, law.invention, Matrix (chemical analysis), chemistry.chemical_compound, Coating, law, General Materials Science, lcsh:TP1-1185, composite, Electrical and Electronic Engineering, lcsh:Science, polydopamine, Magnetite, Graphene, lcsh:T, Aerogel, 021001 nanoscience & nanotechnology, lcsh:QC1-999, 0104 chemical sciences, Nanoscience, chemistry, engineering, lcsh:Q, 0210 nano-technology, Fe3O4 nanoparticles, lcsh:Physics

الوصف: Reduced graphene oxide–magnetite hybrid aerogels attract great interest thanks to their potential applications, e.g., as magnetic actuators. However, the tendency of magnetite particles to migrate within the matrix and, ultimately, escape from the aerogel structure, remains a technological challenge. In this article we show that coating magnetite particles with polydopamine anchors them on graphene oxide defects, immobilizing the particles in the matrix and, at the same time, improving the aerogel structure. Polydopamine coating does not affect the magnetic properties of magnetite particles, making the fabricated materials promising for industrial applications.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1857b17dfa0bc85b4eeb1a21dd0932Test
http://europepmc.org/articles/PMC5827803Test