Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains
| العنوان: | Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains |
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| المؤلفون: | René Grée, Layal Hariss, Ali Hachem, Mirvat Elmasri, Thierry Roisnel, Kamal Bou Hadir |
| المساهمون: | Lebanese University [Beirut] (LU), American University of Beirut [Beyrouth] (AUB), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Research Grant Program at Lebanese University (Lebanon), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Beilstein Journal of Organic Chemistry Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2017, 13, pp.2115-2121. ⟨10.3762/bjoc.13.208⟩ Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2115-2121 (2017) Beilstein Journal of Organic Chemistry, 2017, 13, pp.2115-2121. ⟨10.3762/bjoc.13.208⟩ |
| بيانات النشر: | Beilstein Institut, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 2-a]-N-heterocycles, Mineralogy, imidazo[1, 010402 general chemistry, 01 natural sciences, Coupling reaction, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Nucleophile, Side chain, imidazo[1,2-a]-N-heterocycles, lcsh:Science, Heterocyclic derivatives, Aminopyridines, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010405 organic chemistry, Chemistry, Organic Chemistry, Combinatorial chemistry, 0104 chemical sciences, 3. Good health, gem-difluoroalkyl derivatives, aerobic oxidative coupling, propargylic fluorides, lcsh:Q, Oxidative coupling of methane, Derivative (chemistry) |
| الوصف: | Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed heterocycles of this type play an important role as key core structures of various bioactive compounds. Further, starting with a chloroimidazopyridazine derivative, Pd-catalyzed coupling reactions as well as nucleophilic substitutions have been performed successfully in order to increase the molecular diversity. |
| تدمد: | 1860-5397 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd470379af0a11f7da852b5d1fc35238Test https://doi.org/10.3762/bjoc.13.208Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dd470379af0a11f7da852b5d1fc35238 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18605397 |
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