Water-Soluble Polysaccharide Extracts from the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory Activity
| العنوان: | Water-Soluble Polysaccharide Extracts from the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory Activity |
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| المؤلفون: | Marcello Iacomini, Diego Morales, Alicia Gil-Ramírez, Coen Govers, Fhernanda R. Smiderle, Andriy Synytsya, Harry J. Wichers, Cristina Soler-Rivas |
| المصدر: | International Journal of Medicinal Mushrooms, 19(10), 879-892 International Journal of Medicinal Mushrooms 19 (2017) 10 |
| بيانات النشر: | Begell House, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 02 engineering and technology, Reductase, Pleurotus, Polysaccharide, Applied Microbiology and Biotechnology, 040501 horticulture, chemistry.chemical_compound, Caco2, Polysaccharides, Drug Discovery, Humans, Food science, Enzyme Inhibitors, Food, Health & Consumer Research, VLAG, HMGCR, Pharmacology, chemistry.chemical_classification, Molecular mass, Glycogen, biology, Chemistry, Cell Membrane, Epithelial Cells, Pleurotus ostreatus, 04 agricultural and veterinary sciences, 021001 nanoscience & nanotechnology, biology.organism_classification, In vitro, Molecular Weight, Health & Consumer Research, Cholesterol, Food, Medicinal mushrooms, Hydroxymethylglutaryl CoA Reductases, β-glucans, Caco-2 Cells, 0210 nano-technology, 0405 other agricultural sciences, Digestion |
| الوصف: | Water extracts from Pleurotus ostreatus containing no statins showed 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitory activity (in vitro) that might be due to specific water-soluble polysaccharides (WSPs); when isolated and deproteinized, increasing concentrations of the WSP extract induced higher inhibition. The WSP extract contained mainly β-glucans, mannogalactans, and glycogen (e.g., α-glucans), although derivatives or fragments with lower molecular weights (between 14 and 3.5 kDa) were present and were able to induce the inhibitory activity. The extract contained more β-(1→3)-glucans than β-(11→3),(11→6)-glucans, and they partially survived digestion and managed to pass through Caco2 cell monolayers to the lower compartment after in vitro digestion and transport experiments. The WSP might also modulate Caco2 membrane integrity. |
| وصف الملف: | application/octet-stream; application/pdf |
| تدمد: | 1521-9437 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1444da48a4b3bba309431833e500f360Test https://doi.org/10.1615/intjmedmushrooms.2017024413Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....1444da48a4b3bba309431833e500f360 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15219437 |
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