A New Index for Acute Rejection After Renal Transplant: Notch Receptor-1
| العنوان: | A New Index for Acute Rejection After Renal Transplant: Notch Receptor-1 |
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| المؤلفون: | Kai Zheng, Jinquan Cai, Weizhen Wu, Jianming Tan, Shunliang Yang, Xing-hui Sun |
| المصدر: | Experimental and Clinical Transplantation. 10:433-438 |
| بيانات النشر: | Baskent University, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Graft Rejection, Male, medicine.medical_specialty, Notch signaling pathway, Urology, Renal function, Kidney, Peripheral blood mononuclear cell, Young Adult, chemistry.chemical_compound, medicine, Humans, RNA, Messenger, Receptor, Notch1, Notch 1, Kidney transplantation, Retrospective Studies, Transplantation, Creatinine, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Middle Aged, Flow Cytometry, medicine.disease, Kidney Transplantation, Early Diagnosis, medicine.anatomical_structure, Real-time polymerase chain reaction, chemistry, Acute Disease, Leukocytes, Mononuclear, Female, business, Biomarkers |
| الوصف: | OBJECTIVES: This study aimed at investigating the relation between expression of Notch receptor-1 (Notch 1) in peripheral blood mononuclear cells and acute rejection after renal transplant. MATERIALS AND METHODS: Ninety-seven patients receiving a renal transplant were randomly selected. Peripheral blood samples before transplant and days 1, 3, 5, 7, 10, 14, 21, and 30 after transplant were retrospectively observed. Expression of Notch 1 was detected by flow cytometry and real-time quantitative polymerase chain reaction. RESULTS: Expression of Notch 1 was correlated with acute rejection and long-term renal function after transplant (as detected by the level of serum creatinine 6 months after transplant). Expression of Notch 1 in peripheral blood mononuclear cells increased before serum creatinine increased. Expression of Notch 1 can reveal the immune state of recipients after transplant, and Notch 1 expression at early time points after transplant can predict long-term renal function. CONCLUSIONS: Notch 1 can serve as an important index for acute rejection and long-term renal function after transplant. |
| تدمد: | 2146-8427 1304-0855 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72a1dde65a6d37ab62f9189f3afe23aTest https://doi.org/10.6002/ect.2011.0166Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e72a1dde65a6d37ab62f9189f3afe23a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21468427 13040855 |
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