Xanthine oxidase inhibitory activity of compounds from Chythrantus claneianus
| العنوان: | Xanthine oxidase inhibitory activity of compounds from Chythrantus claneianus |
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| المؤلفون: | Bruno Ndjakou Lenta, Silvère Ngouela, Muhammad Ali, Eric René Sieliatchom Nkanwen, Etienne Tsamo, Akif Alakbar Guliyev, Angelbert F. Awantu, Diderot T. Noungoue, Anar Sahib Gojayev, Jean Jules Kezetas Bankeu |
| المصدر: | Bangladesh Journal of Pharmacology. 8 |
| بيانات النشر: | Bangladesh Journals Online (JOL), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Pharmacology, chemistry.chemical_classification, Stereochemistry, medicine.drug_class, Umbelliferone, Inhibitory postsynaptic potential, In vitro, chemistry.chemical_compound, Enzyme, chemistry, Phytochemical, Biochemistry, Scopoletin, medicine, Xanthine oxidase, Xanthine oxidase inhibitor |
| الوصف: | Phytochemical investigation of the stem bark and the trunk of Chythrantus claneianus led to the isolation of six known compounds named β-sitosterol (1), umbelliferone (2), scopoletin (3), benjaminamide (4), β-sitosterol-3-O-β-D-glucopyranoside (5) and Panconoside B (6). All these compounds were isolated for the first time from this plant species. The chemical structures of isolates were elucidated on the basis of 1 and 2 D-NMR spectra and other spectroscopic techniques including UV–vis, FT-IR, HR-ESIMS and HR-FABMS. The isolates were tested in vitro for their inhibitory properties towards xanthine oxidase enzyme. Compounds 2, 3 and 6 showed weak inhibi-tory activities on the enzyme with IC 50 values ranging from 307 µM for com-pound 6 to 475 µM for compound 3, while the extract and compounds 1, 4 and 5 showed extremely weak activities with inhibition percentage less than 50%. |
| تدمد: | 1991-0088 1991-007X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::4cc3b8574304e610b87973a8748332d3Test https://doi.org/10.3329/bjp.v8i1.13485Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........4cc3b8574304e610b87973a8748332d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19910088 1991007X |
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