مراجعة
Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours
| العنوان: | Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours |
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| المؤلفون: | Yozgat, Ahmet, Kekilli, Murat, Altay, Mustafa |
| بيانات النشر: | Baishideng Publishing Group Inc |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Enterochromaffm cells, 68Ga-DOTATATE, Gastrointestinal, Neuroendocrine tumours, Somatostatin receptor, Targeted peptide receptor radiotherapy, Zollinger-Ellison-Syndrome, Enets Consensus Guidelines, Endocrine Neoplasia Type-1, Clinical-Practice Guidelines, Gastric Carcinoids, Follow-Up, Surgical-Management, Chromogranin-A, Small-Bowel, Statistical Evaluation |
| الوصف: | Neuroendocrine tumors (NETs) are a rare and heterogeneous disease group and constitute 0.5% of all malignancies. The annual incidence of NETs is increasing worldwide. The reason for the increase in the incidence of NETs is the detection of benign lesions, incidental detection due to the highest use of endoscopic and imaging procedures, and higher recognition rates of pathologists. There have been exciting developments regarding NET biology in recent years. Among these, first of all, soma tosta tin receptors and downstream pathways in neuroendocrine cells have been found to be important regulatory mechanisms for protein synthesis, hormone secretion, and proliferation. Subsequently, activation of the mammalian target of rapamycin pathway was found to be an important mechanism in angiogenesis and tumor survival and cell metabolism. Finally, the importance of proangiogenic factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblastic growth factor, angiopoietin, and semaphorins) in the progression of NET has been determined. Using the combination of biomarkers and imaging methods allows early evaluation of the appropriateness of treatment and response to treatment. |
| نوع الوثيقة: | review |
| اللغة: | English |
| تدمد: | 2307-8960 |
| العلاقة: | World Journal of Clinical Cases; Diğer; https://doi.org/10.12998/wjcc.v9.i29.8627Test; https://hdl.handle.net/20.500.14065/3024Test; 29; 8627; 8646; WOS:000749647500001; 2-s2.0-85119211227 |
| DOI: | 10.12998/wjcc.v9.i29.8627 |
| الإتاحة: | https://doi.org/10.12998/wjcc.v9.i29.8627Test https://doi.org/20.500.14065/3024Test https://hdl.handle.net/20.500.14065/3024Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A3771ADE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23078960 |
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| DOI: | 10.12998/wjcc.v9.i29.8627 |