دورية أكاديمية
Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury ; Effect of DMF on liver I/R
| العنوان: | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury ; Effect of DMF on liver I/R |
|---|---|
| المؤلفون: | Takasu, Chie, Vaziri, Nosratola D, Li, Shiri, Robles, Lourdes, Vo, Kelly, Takasu, Mizuki, Pham, Christine, Farzaneh, Seyed H, Shimada, Mitsuo, Stamos, Michael J, Ichii, Hirohito |
| بيانات النشر: | Baishideng Publishing Group |
| سنة النشر: | 2021 |
| المجموعة: | Tokushima University Institutional Repository / 徳島大学機関リポジトリ |
| مصطلحات موضوعية: | Inflammation, Reactive oxidative stress, Nrf2, Ischemia, Dimethyl fumarate, Liver |
| الوصف: | AIM To investigate the hypothesis that treatment with dimethyl fumarate (DMF) may ameliorate liver ischemia/reperfusion injury (I/RI). METHODS Rats were divided into 3 groups: sham, control (CTL), and DMF. DMF (25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase (ALT) and malondialdehyde (MDA) levels, adenosine triphosphate (ATP), NO × metabolites, anti-oxidant enzyme expression level, anti-inflammatory effect, and anti-apoptotic effect were determined. RESULTS Histological tissue damage was significantly reduced in the DMF group (Suzuki scores: sham: 0 ± 0; CTL: 9.3 ± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT (DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA (DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content (DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity (DMF 7.8 ± 0.4 mU/mL vs CTL 6.0 ± 0.5 mU/mL, P = 0.01) and level of endothelial nitric oxide synthase expression (DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes (catalase and glutamate-cysteine ligase modifier subunit and lower levels of key inflammatory mediators (nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group. CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 10079327 22192840 |
| العلاقة: | http://repo.lib.tokushima-u.ac.jp/files/public/11/115828/20210317115802179305/wjg_23_25_4508.pdfTest; AA11690631; http://repo.lib.tokushima-u.ac.jp/115828Test |
| الإتاحة: | http://repo.lib.tokushima-u.ac.jp/115828Test |
| حقوق: | This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.17568B7D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10079327 22192840 |
|---|