دورية أكاديمية
Normal serum alanine aminotransferase activity in uncomplicated obesity
| العنوان: | Normal serum alanine aminotransferase activity in uncomplicated obesity |
|---|---|
| المؤلفون: | G. Iacobellis, A. Moschetta, M. C. Ribaudo, A. Zappaterreno, C. V. Iannucci, LEONETTI, Frida |
| المساهمون: | G., Iacobelli, A., Moschetta, M. C., Ribaudo, A., Zappaterreno, C. V., Iannucci, Leonetti, Frida |
| بيانات النشر: | BAISHIDENG PUBL GRP CO LTD |
| سنة النشر: | 2005 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | insulin resistance, obesity, serum alanine aminotransferase activity |
| الوصف: | AIM: To evaluate serum alanine aminotransferase (ALT) activity in a well-characterized group of uncomplicated obese subjects and its correlation with insulin resistance, plasma adiponectin, and leptin concentrations. METHODS: One hundred and five uncomplicated obese subjects (87 women, 18 men, age 34.3 +/- 9.6 years, BMI 39.9 +/- 8.3 kg/m(2)) were studied. Serum ALT activity was evaluated. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp (M index) and fasting insulin. Plasma leptin and adiponectin levels were also measured. RESULTS: Serum ALT concentration in the whole group of uncomplicated obese subjects was 17.73 +/- 6.33 U/L with none of the subjects presenting ALT levels greater than 43 U/L and only 9 (11%) women and 3 (19%) men showed ALT levels >19 and >30 U/L for women and men, respectively. No significant difference was detected in serum ALT levels between severe obese subjects (BMI >40 kg/m(2)) and those with BMI < 40 kg/m(2) (18.63 +/- 6.25 vs 17.26 +/- 6.02 U/L). ALT was significantly correlated with fasting insulin (r = 0.485, P = 0.02) and triglycerides (r = 0.358, P = 0.03). CONCLUSION: Serum ALT activity is practically normal in uncomplicated obese subjects, independently of their obesity degree. These findings suggest the role of obesityrelated comorbidities and not of BMI as main risk factors for elevated ALT levels in obese subjects. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/16273617; info:eu-repo/semantics/altIdentifier/wos/WOS:000208331000019; volume:11; issue:38; firstpage:6018; lastpage:6021; numberofpages:4; journal:WORLD JOURNAL OF GASTROENTEROLOGY; http://hdl.handle.net/11573/114092Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-28644437877; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000208331000019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest; http://www.scopus.com/inward/record.url?eid=2-s2.0-28644437877&partnerID=65&md5=9558a8df7befe9957e03959e21f070b5Test |
| الإتاحة: | http://hdl.handle.net/11573/114092Test http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000208331000019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest http://www.scopus.com/inward/record.url?eid=2-s2.0-28644437877&partnerID=65&md5=9558a8df7befe9957e03959e21f070b5Test |
| رقم الانضمام: | edsbas.D9989328 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |