Heidland, A, Sebeková, K, Frangiosa, A, DE SANTO, Luca Salvatore, Cirillo, M, Rossi, F, Cotrufo, M, Perna, Alessandra, Klassen, A, Schinzel, R, De Santo, N. G., Sebekova, K, DE SANTO, L, Cirillo, Massimo, Perna, A, DE SANTO, N. G.
Objectives: To analyse circulating concentrations of advanced glycation end products (AGEs) in patients with severe congestive heart failure (CHF) and after heart transplantation; to identify the potential contribution of kidney function to plasma AGE concentrations; and to determine whether AGE concentrations and parameters of oxidative stress are interrelated.Methods and results: Circulating N-epsilon-(carboxymethyl) lysine (CML) and AGE associated fluorescence (AGE-Fl), lipid peroxidation, and glomerular filtration rate (GFR) were measured in a cross sectional study of 22 patients with advanced CHF, 30 heart transplant recipients, and 20 healthy controls. Compared with the controls, the CHF patients had decreased CML (mean(SEM) 467.8 (20.0) ng/ml v 369.3 (22.3) ng/ml, p
