Tik Bozuklugu ve Obsessif Kompulsif Bozuklugu Olan Cocuklarin Serum Orneklerinde Antinoronal, Hucre Iskeleti ve Antinuklear Antikorlar
| العنوان: | Tik Bozuklugu ve Obsessif Kompulsif Bozuklugu Olan Cocuklarin Serum Orneklerinde Antinoronal, Hucre Iskeleti ve Antinuklear Antikorlar |
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| المؤلفون: | Rukiye Eker Omeroglu, Sema İçöz, Işık Görker, Nuray Gürel Polat, Gülşen Akman Demir, Ümran Tüzün, Piraye Serdaroğlu |
| المصدر: | Balkan Medical Journal. |
| بيانات النشر: | AVES Publishing Co., 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Movement disorders, biology, business.industry, Antinuclear antibody positivity, Autoantibody, General Medicine, medicine.disease, medicine.disease_cause, Group A, Autoimmunity, Pathogenesis, PANDAS, mental disorders, Immunology, biology.protein, Medicine, Antibody, medicine.symptom, business |
| الوصف: | Objective: As environmental factors, the role of Group A beta hemolytic streptococcus infections in the development of tic and obsessive compulsive disorders (OCD) is controversial. The autoimmune hypothesis states that during infection, formation of autoantibodies leads to an autoimmune disorder, which in turn results in movement disorders, tic disorders and/or OCD. In order to test this hypothesis, we assayed these antibodies in children and adolescents diagnosed with tic disorders and/or OCD. Material and Methods: Children and adolescents who were diagnosed with either tic disorders or OCD according to DSM-IV criteria (n=28), were compared with healthy controls (n=15) having similar age and gender characteristics. Regardless of a streptococcus infection history, serum samples of all patients and controls underwent antinuclear, cytoskeletal, and antineuronal antibody assay using indirect immunofluorescence. Results: The rates of antinuclear antibody positivity were 21% and 20% in the patient and control groups respectively (pg0.05). Antineuronal antibody was positive in 2 (7%) of 28 patients versus in 1 (6%) of 15 controls (pg0.05). Conclusion: These results suggest that such antibodies may not be involved in the pathogenesis of tic disorders/OCD. |
| تدمد: | 2146-3131 2146-3123 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::bdf55b91fdeafaf893cae7f503619d54Test https://doi.org/10.5152/balkanmedj.2011.020Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........bdf55b91fdeafaf893cae7f503619d54 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21463131 21463123 |
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