The protective effect of L-carnitine on hepatic ischemia-reperfusion injury in rats
| العنوان: | The protective effect of L-carnitine on hepatic ischemia-reperfusion injury in rats |
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| المؤلفون: | Muharrem Taskoparan, Sedat Boyacioglu, Gürden Gür, D. Aldemir, Suna Turkoglu, Ugur Yilmaz, Ayhan Hilmi Çekin, M. Gürsoy |
| المصدر: | The Turkish Journal of Gastroenterology. 24:51-56 |
| بيانات النشر: | AVES Publishing Co., 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Antioxidant, medicine.medical_treatment, Liver transplantation, Lipid peroxidation, chemistry.chemical_compound, Postoperative Complications, Carnitine, Malondialdehyde, Internal medicine, Lactate dehydrogenase, medicine, Animals, Aspartate Aminotransferases, Rats, Wistar, business.industry, Liver Diseases, Gastroenterology, Alanine Transaminase, Glutathione, medicine.disease, Liver Transplantation, Rats, Surgery, Disease Models, Animal, Oxidative Stress, Endocrinology, chemistry, Reperfusion Injury, Vitamin B Complex, Lipid Peroxidation, business, Reperfusion injury, medicine.drug |
| الوصف: | BACKGROUND/AIMS Ischemia-reperfusion injury may occur during liver transplantation and remains a serious concern in clinical practice. This study was designed to study the potential benefit of L-carnitine on experimental warm hepatic ischemia-reperfusion injury in rats. MATERIALS AND METHODS Forty-five male Wistar Albino rats were divided into three groups; Group 1 sham-operation without ischemia-reperfusion (n=15); Group 2, ischemia-reperfusion (n=15); and Group 3, which was administered L-carnitine (200 mg/kg, intraperitoneal, for 4 days) prior to ischemia-reperfusion (n=15). The study animals were then sacrificed to obtain hepatic tissue and serum samples. Tissue levels of malondialdehyde and reduced glutathione and serum levels for aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase were assessed. RESULTS Mean aspartate aminotransferase levels were significantly higher in Group 2 (405.2 U/L) when compared to Groups 1 (137.1 U/L) and 3 (267.6 U/L). Mean alanine aminotransferase levels were significantly higher in Group 2 (257.1 U/L) when compared to Groups 1 (37.2 U/L), and 3 (118.1 U/L) (p< 0.001 for each). Mean lactate dehydrogenase levels were significantly higher in Group 2 (2943.8 U/L) when compared to Groups 1 (1496.5 U/L), and 3 (2185.3U/L) (p < 0.001 for each). Mean malondialdehyde levels were significantly higher in Group 2 (54.3 nmol/g) compared to Groups 1 (41.0 nmol/g) and 3 (42.1 nmol/g) (p < 0.001 for each). Mean reduced glutathione levels were significantly lower in Group 2 (5.9 nmol/mg) and Group 3 (7.4 nmol/mg) compared to Group 1 (9.1 nmol/mg) (p < 0.001 for each). CONCLUSIONS In conclusion, our data supports a protective effect of L-carnitine against oxidative damage in hepatic ischemia-reperfusion injury in rats. This is evidenced by improvement of the antioxidant defense system and lipid peroxidation levels. |
| تدمد: | 2148-5607 1300-4948 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649aeca45813ee383936eb7c4e475386Test https://doi.org/10.4318/tjg.2013.0645Test |
| رقم الانضمام: | edsair.doi.dedup.....649aeca45813ee383936eb7c4e475386 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21485607 13004948 |
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