دورية أكاديمية
Role of tissue transglutaminase in age-associated ventricular stiffness
| العنوان: | Role of tissue transglutaminase in age-associated ventricular stiffness |
|---|---|
| المساهمون: | College of Medicine, Dept. of Anesthesiology and Pain Medicine, Young Jun Oh, Vanessa C. Pau, Jochen Steppan, Gautam Sikka, Valeriani R. Bead, Daniel Nyhan, Benjamin D. Levine, Dan E. Berkowitz, Lakshmi Santhanam, Oh, Young Jun |
| بيانات النشر: | Springer-Verlag Austria |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Aging/metabolism, Aging/pathology, Animals, Blood Pressure, Cystamine/pharmacology, Echocardiography, Elasticity, Enzyme Inhibitors/pharmacology, Extracellular Matrix/drug effects, Extracellular Matrix/enzymology, Extracellular Matrix/pathology, GTP-Binding Proteins/antagonists & inhibitors, GTP-Binding Proteins/genetics, GTP-Binding Proteins/metabolism, Gene Expression, Heart Ventricles/enzymology, Heart Ventricles/physiopathology, Hypertrophy, Left Ventricular/enzymology, Left Ventricular/genetics, Left Ventricular/physiopathology, Left Ventricular/prevention & control, Infusion Pumps, Implantable, Male, Myocardium/enzymology, Myocardium/pathology, Myocytes, Cardiac/drug effects, Cardiac/enzymology |
| الوصف: | Aging is associated with increased cardiomyocyte loss, left-ventricular hypertrophy, and the accumulation of extracellular matrix, which results in declining cardiac function. The role of the matrix crosslinking enzyme, tissue transglutaminase (TG2), in age-related myocardial stiffness, and contractile function remains incompletely understood. In this study, we examined the role of TG2 in cardiac function, and determined whether TG2 inhibition can prevent age-associated changes in cardiac function. Male Fisher rats (18-month-old) were administered the transglutaminase inhibitor cystamine (study group) or saline (age-matched controls) for 12 weeks via osmotic mini-pumps. Cardiac function was determined by echocardiography and invasive pressure-volume loops. Rat hearts were dissected out, and TG2 expression, activity, and S-nitrosation were determined. Young (6-month-old) males were used as controls. TG2 activity significantly increased in the saline-treated but not in the cystamine-treated aging rat hearts. TG2 expression also increased with age and was unaltered by cystamine treatment. Aged rats showed increased left ventricular (LV) end-systolic dimension and a decrease in fractional shortening compared with young, which was not affected by cystamine. However, cystamine treatment preserved the preload-independent index of LV filling pressure and restored end-diastolic pressure, end-diastolic pressure-volume relationships, and arterial elastance toward young. An increase in TG2 activity contributes to age-associated increase in diastolic stiffness, thereby contributing to age-associated diastolic dysfunction. TG2 may thus represent a novel target for age-associated diastolic heart failure. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0939-4451 1438-2199 |
| العلاقة: | AMINO ACIDS; J00124; OAK-2017-02375; https://ir.ymlib.yonsei.ac.kr/handle/22282913/154304Test; https://link.springer.com/article/10.1007%2Fs00726-016-2295-zTest; T201701808; AMINO ACIDS, Vol.49(3) : 695-704, 2017 |
| DOI: | 10.1007/s00726-016-2295-z |
| الإتاحة: | https://doi.org/10.1007/s00726-016-2295-zTest https://ir.ymlib.yonsei.ac.kr/handle/22282913/154304Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.BA3C4F4F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09394451 14382199 |
|---|---|
| DOI: | 10.1007/s00726-016-2295-z |