دورية أكاديمية
Radiological-pathological correlation study of hepatocellular carcinoma undergoing local chemoradiotherapy and surgery
| العنوان: | Radiological-pathological correlation study of hepatocellular carcinoma undergoing local chemoradiotherapy and surgery |
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| المساهمون: | College of Medicine, Dept. of Radiation Oncology, Jun Won Kim, Jinsil Seong, Mi Sook Park, Kyung Sik Kim, Young Nyun Park, Kwang Hyub Han, Ki Chang Keum, Ik Jae Lee, Keum, Ki Chang, Kim, Kyung Sik, Kim, Jun Won, Park, Mi Sook, Park, Young Nyun, Seong, Jin Sil, Lee, Ik Jae, Han, Kwang Hyup, Park, Mi-Suk |
| بيانات النشر: | Blackwell Scientific Publications Australia |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | hepatocellular carcinoma, localized chemoradiotherapy, radiologic-pathologic correlation |
| الوصف: | BACKGROUND AND AIMS: Optimal response criteria and assessment timing were investigated through radiologic-pathologic correlation in hepatocellular carcinoma (HCC) treated with localized chemoradiotherapy (CRT). METHODS: We reviewed 19 consecutive HCC patients who underwent surgical resection after radiotherapy and concurrent hepatic arterial infusion chemotherapy. Patients who received transarterial chemoembolization before RT or surgery were excluded from evaluation. Tumor diameters and total and enhancing tumor volumes were measured from CT images obtained 1, 3, 6, and 9?months after CRT. Percent changes calculated using size (RECIST and WHO) and enhancement criteria (mRECIST and EASL) were correlated with percent changes in total and enhancing tumor volumes, and with percent viable tumor in surgical specimens. RESULTS: Median time between CRT and resection was 4.1?months (range, 1.5-15.4?months). CR and PR rates were 0 and 68% by RECIST, 0 and 63% by WHO, 53% and 37% by mRECIST, and 53% and 42% by EASL. Pathologic CR (pCR) rate was 52.6%. Radiologic criteria showed strong correlation with tumor volumes at 1 and 3?months after CRT; at 6?months, however, size and enhancement criteria showed strong correlation only with total and enhancing tumor volumes, respectively. Enhancement criteria were better predictors of pathologic response at all times including preoperative evaluation (RECIST: R(2) ?=?0.303, P?=?0.015 and WHO: R(2) ?=?0.366, P?=?0.006 vs. mRECIST: R(2) ?=?0.760, P?6?months before resection showed significant correlation with pCR (P?=?0.013). CONCLUSIONS: We recommend using enhancement criteria in assessing tumor viability, especially if the tumor was to be resected <6?months after CRT. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0815-9319 1440-1746 |
| العلاقة: | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY; J01417; OAK-2016-05884; https://ir.ymlib.yonsei.ac.kr/handle/22282913/152220Test; T201603806; JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.31(9) : 1619-1627, 2016 |
| DOI: | 10.1111/jgh.13334 |
| DOI: | 10.1111/jgh.13334/abstract |
| الإتاحة: | https://doi.org/10.1111/jgh.13334Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/152220Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.ABCEDC3F |
| قاعدة البيانات: | BASE |
| تدمد: | 08159319 14401746 |
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| DOI: | 10.1111/jgh.13334 |