دورية أكاديمية
Phase II trial of niraparib for
| العنوان: | Phase II trial of niraparib for |
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| المؤلفون: | Kawamoto, Yasuyuki, Morizane, Chigusa, Komatsu, Yoshito, Kondo, Shunsuke, Ueno, Makoto, Kobayashi, Satoshi, Furukawa, Masayuki, Lee, Lingaku, Satoh, Taroh, Sakai, Daisuke, Ikeda, Masafumi, Imaoka, Hiroshi, Miura, Arisa, Hatanaka, Yutaka, Yokota, Isao, Nakamura, Yoshiaki, Yoshino, Takayuki |
| المصدر: | Future Oncol ; ISSN:1744-8301 |
| بيانات النشر: | Atypon |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | BRCA, biliary tract cancer, gastrointestinal cancer, genetic testing, niraparib, pancreatic cancer |
| الوصف: | Due to the widespread use of cancer genetic testing in gastrointestinal cancer, the BRCA1/2 genetic mutation has been identified in biliary tract cancer as well as pancreatic cancer. Niraparib is a poly(ADP-ribose) polymerase (PARP) inhibitor, and PARP inhibitors exert their cytotoxicity against cancer cells in the context of homologous recombination deficiency, such as BRCA mutations, via the mechanism of synthetic lethality. The aim of this phase II NIR-B trial is to evaluate the efficacy and safety of niraparib for patients with unresectable advanced or recurrent biliary tract cancer, pancreatic cancer or other gastrointestinal cancers with germline or somatic BRCA1/2 mutations revealed by genetic testing. The primary end point is an investigator-assessed objective response rate in each cohort.Clinical Trial Registration: jRCT2011200023 (ClinicalTrials.gov). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.2217/fon-2023-0348Test; https://pubmed.ncbi.nlm.nih.gov/38629456Test |
| DOI: | 10.2217/fon-2023-0348 |
| الإتاحة: | https://doi.org/10.2217/fon-2023-0348Test https://pubmed.ncbi.nlm.nih.gov/38629456Test |
| رقم الانضمام: | edsbas.BEFD22DB |
| قاعدة البيانات: | BASE |
| DOI: | 10.2217/fon-2023-0348 |
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