تقرير
Evaluating the Diagnostic Efficacy of
| العنوان: | Evaluating the Diagnostic Efficacy of |
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| المؤلفون: | Kumar, Pardeep, Kumar, Aishwarya, Nagaraj, Chandana, Sadashiva, Nishanth, Saini, Jitender, Mangalore, Sandhya, Rajan, Archith, Sitani, Keerti, Beniwal, Manish, Santosh, Vani, Basavaraja, Harish, Hazari, Puja Panwar, Mishra, Anil Kumar |
| المصدر: | Cancer Biother Radiopharm ; ISSN:1557-8852 ; Volume:39 ; Issue:5 |
| بيانات النشر: | Atypon |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | PET-MRI, SPECT-CT, [11C]methionine, [99mTc]Tc-methionine |
| الوصف: | Background: Amino acid positron emission tomography (PET) imaging plays a significant role in the diagnosis of gliomas and in differentiating tumor recurrence from necrosis. In this study, the authors evaluated the diagnostic efficacy of [99mTc]Tc-methionine single-photon emission computed tomography-computed tomography (SPECT-CT) in comparison with [11C]methionine PET-magnetic resonance imaging (MRI) in delineating tumors. Methods: Thirty-one (primary: 16 and postoperative: 15) patients of confirmed (either MRI or histopathological proven) glioma underwent both [99mTc]Tc-methionine SPECT-CT and [11C]methionine PET-MRI. A comparative analysis was performed between SPECT, PET, and MR images to calculate the concordance between the modalities and to evaluate the diagnostic efficacy of the [99mTc]Tc-methionine SPECT. Results: [99mTc]Tc-methionine SPECT showed comparable uptake in the tumor lesions in comparison to [11C]methionine PET. A significant and strong positive correlation was observed between the volume of tumor (Vt) in PET and Vt MR (p < 0.004). Likewise, a significant and strong positive correlation was found between Vt SPECT and Vt MR. [99mTc]-methionine has a sensitivity and specificity of 91% and 75%, respectively, compared with 82% and 100% for [11C]methionine in postoperative cases to differentiate the tumor recurrence from necrosis. The sensitivity and specificity of [99mTc]Tc-methionine was 92% and 100%, respectively, compared with 92% and 67% for [11C]methionine in primary tumors. Conclusion: [99mTc]Tc-methionine SPECT-CT is as equally good as [11C]methionine for diagnosing and differentiating it from necrosis especially in high-grade glioma. |
| نوع الوثيقة: | report article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1089/cbr.2023.0147Test; https://pubmed.ncbi.nlm.nih.gov/38324045Test |
| DOI: | 10.1089/cbr.2023.0147 |
| الإتاحة: | https://doi.org/10.1089/cbr.2023.0147Test https://pubmed.ncbi.nlm.nih.gov/38324045Test |
| رقم الانضمام: | edsbas.9B41A392 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1089/cbr.2023.0147 |
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